Possible genetic cause of obesity in children discovered Health and Wellbeing
(ANSA) – ROME, MAY 04 – A causal genetic variant strongly associated with childhood obesity has been identified: the discovery is due to pediatricians at the Children’s Hospital of Philadelphia (Chop) and is published in the journal Cell Genomics.
The study provides new insights into the importance of a region of the nervous system, the hypothalamus, and its role in common childhood obesity. The gene could serve as a tractable target for future therapies.
Both environmental and genetic factors play critical roles in the increased incidence of childhood obesity.
Previous studies show that neuronal pathways in the hypothalamus regulate food consumption and are key regulators of disease.
By comparing the genome of obese children with that of normal weight peers, pediatricians have identified a specific genetic variant strongly associated only with childhood obesity and not with adult obesity; the gene is located on chromosome 12 and is called ‘rs7132908’ and is located near the FAIM2 gene important for the development of the nervous system.
“The discovered variant is associated with one of the strongest genetic signals ever found for childhood obesity,” explains first author Sheridan Littleton. In test-tube experiments, the researchers demonstrated that this variant is potentially associated with a reduction in neurons in the hypothalamic region.
Stallergenes Greer Study Shows Significant Reduction in Asthma Risk: EfficAPSI Published in The Lancet Learn More!
2024-05-06 08:46:14
Stallergenes Greer, a biopharmaceutical laboratory specializing in allergen immunotherapy (ITA), announces the results of its real-world study, EfficAPSI, evaluating the effect of its sublingual ITA solutions on the onset and progression of asthma in patients with allergic rhinitis, was published in the journal The Lancet Regional Health-Europe. This article has already been published online (https://doi.org/10.1016/j.lanepe.2024.100915), will soon be available in print.
This real-life longitudinal and retrospective pharmaco-epidemiological study evaluated, over a period of 9 years, more than 440,000 patients: more than 110,000 patients suffering from allergic rhinitis, with or without asthma, treated with Stallergenes Greer sublingual solutions and symptomatic medications; compared with more than 330,000 patients suffering from allergic rhinitis, with or without asthma, treated only with symptomatic drugs.
The main objective of the study was to evaluate the real effect of Stallergenes Greer sublingual solutions in preventing the onset and exacerbation of asthma in patients with allergic rhinitis. The results of the study are consistent across all age categories (from 5 years), allergens and evaluation criteria.
EfficAPSI showed, in patients treated with Stallergenes Greer sublingual solutions and symptomatic medications, compared to patients treated with only symptomatic medications:
- a 36% reduction in the risk of new asthma attacks across the cohort*;
Acalabrutinib, venetoclax and obinutuzumab in relapsed CLL
#Acalabrutinib #venetoclax #obinutuzumab #relapsed #CLL
Key message:
In the phase II CLL2-BAAG trial, the efficacy of measurable residual disease (MRD)-guided triple therapy comprising acalabrutinib, venetoclax, and obinutuzumab was evaluated in 45 patients with relapsed/refractory CLL. MRD was assessed by flow cytometry in peripheral blood, while ctDNA was examined by PCR. After 6 months of triple therapy, the rate of undetectable MRD reached 75.6%, increasing to 93.3% during a median follow-up of 36.3 months (94.4% among patients with TP53 mutations). Importantly, the 3-year progression-free survival and overall survival rates were 85.0% and 93.8%, respectively. Of the 18 MRD occurrences identified, only 5 resulted in clinical progression.
These findings underscore the effectiveness of MRD-guided therapy, highlighting its potential as a robust treatment approach and advocating for the integration of ctDNA assessment into routine clinical practice.
Summary:
The phase 2 CLL2-BAAG trial tested the measurable residual disease (MRD)-guided triple combination of acalabrutinib, venetoclax, and obinutuzumab after optional reduction with bendamustine in 45 patients with relapsed/refractory CLL (one patient was excluded from the analysis due to a violation of the exclusion criteria).
Alarm at the Verona hospital: the killer bacterium of newborns returns, closing the department as a precaution Health and Wellbeing
The Borgo Trento hospital in Verona is currently on high alert after a bacterium was allegedly found in the maternity ward, prompting the suspension of admissions to the neonatal intensive care unit as a precautionary measure. The results of the ongoing analyzes on the bacterium are expected to be available by tomorrow, Tuesday, May 7.
The alarm was sounded after three children tested positive for the bacterium during recent screenings, although fortunately they did not develop any serious illnesses. This concern is exacerbated by a previous incident at the same hospital in June 2020, where the maternity ward was shut down due to a series of severe infections caused by Citrobacter found in the taps, resulting in the death and injuries of newborns.
Professor Ercole Concia, former director of the Infectious Diseases Unit of the Aoui, expressed serious concern over the situation, stating that if the bacterium is indeed Citrobacter, drastic measures must be taken to ensure the safety of newborns.
Citrobacter is a genus of bacteria that can be found in various environments, including water and food. It is a normal component of the intestinal bacterial flora but can cause infections in vulnerable individuals such as infants,
Protect Your Eyes: Tips for Selecting and Wearing Sunglasses, According to Ophthalmologist
**Health: Selecting the Right Sunglasses to Protect Your Eyes**
It’s a cautionary tale that has garnered millions of views on TikTok. A user named Courtney shared her experience with allegedly purchasing “cheap” sunglasses that failed to protect her eyes from harmful UV rays. As a result, she was diagnosed with pinguecula – harmless yellow-colored growths on the white part of both her eyes.
Courtney’s situation serves as a valuable lesson for all of us – selecting and wearing the right sunglasses is crucial for protecting our eyes from potential sun damage. In this article, we will discuss some tips provided by world-renowned ophthalmologist, Dr. Brian Boxer Wachler, to help you make informed decisions when choosing sunglasses.
The Importance of UV Protection
Cheap sunglasses can be found all over online marketplaces like Amazon. However, according to Dr. Boxer Wachler, it’s crucial to ensure they meet quality standards and provide sufficient protection against harmful UV rays. Many cheaply-made sunglasses from foreign markets may lack proper UV protection measures, presenting potential risks.
Understanding Standards
To guarantee adequate protection against UV rays, it’s important to look for specific indicators on sunglass labels.
The Secret to Youthful Skin: Regenerate Cells with Essential Proteins
The answer to glowing and firm skin can be found in our body’s fundamental molecules: proteins.
Our skin is a dynamic organ, constantly renewing itself. Skin cells are regenerated with the help of three proteins, which are the basic “bricks” of the skin.
Proteins are key building blocks of our cells, contributing to structure, elasticity and function. In the case of the skin, three basic proteins play a vital role in maintaining health and a youthful appearance.
The collagen it is the main protein in the skin and represents about 75% of the mass. Collagen gives the skin firmness and elasticity, helping to prevent the appearance of wrinkles and sagging.
Elastin It depends on skin elasticity. This protein allows the skin to stretch and return to its original shape, thus reducing the appearance of wrinkles and loss of firmness.
Keratin meet and hair, offering protection against environmental factors and maintaining their integrity.
Proteins are the real magic ingredients of our skin. Collagen, elastin and keratin are essential elements for maintaining the elasticity, firmness and health of our skin. By adopting a healthy lifestyle, which includes external and internal care,
sport, a simple prescription for sleeping better
FRANCE 5 – TUESDAY APRIL 23 AT 9:05 P.M. – MAGAZINE
To be in Olympic shape, moving is a necessity. But it is also necessary to sleep well. So much so that in strategies to optimize athlete performance, sleep is an integral part of preparation.
For ordinary people who are not aiming for an Olympic medal but trying to stay healthy as long as possible, the alliance between regular physical activity and quality of sleep is also necessary.
This issue of the health magazine “Take care of yourself!” », animated with education and a touch of humor by Michel Cymes, looks at the most effective methods to overcome sleep disorders.
A general public problem, since it is estimated that 30% of French people suffer from these inconveniences. Beyond debilitating daily fatigue, they can promote worrying phenomena such as hypertension, the risk of stroke or depression.
Digital curfew
For half a century, the French have lost an hour and a half of daily sleep. According to recent studies, we sleep on average 6 hours 41 minutes per night, while an adult needs a minimum of seven to eight hours of sleep.
Optimizing Exercise Times for Maximum Effectiveness
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What to do with children who want to be alone? 2024-05-06 02:13:40
Sometimes children, like adults, try to be lonely, to be alone for a certain period of time.
Of course, this is usually an adult desire, but children also sometimes crave to be alone. In particular, being alone is very important for babies, children and teenagers in terms of personality development.
We often think that babies and children need constant supervision. Yes, children need supervision, but children also need solitude. Children’s ability to spend time on their own helps them develop in many ways, from independence to impulse control.
On topic expert-clinical psychologist Narync Rustamova Publika.azsaid in his statement that in general, leaving children alone should not be equated with leaving them unsupervised. At a certain age, children’s needs for games and toys change in different ways.
“It should be noted that children under the age of 3 prefer to play alone. After the age of 3, they show interest in collective games, which we call “parallel game”. These also play a certain role in the development of the child at such a time. By the age of 3, children play one-sided games by dividing the toy into parts, re-thinking and combining the toys they divided into parts,