Because organoids which are miniature and very precise representations of organs which reproduce as faithfully as possible their structure and their unique functions make it possible to test endless and practically without cost. And if organoid technology is successful in itself an exponential success and development in medical and scientific research, artificial intelligence (AI) and the edition of genome, among other major advances, multiply and still accelerate its applications.
A review (1) offers a detailed exploration of the origins and characteristics of the different types of organoids and their applications, in particular in:
- disease modeling,
- evaluations of toxicity and the effectiveness of drugs,
- precision medicine,
- Regenerative medicine.
This photograph delivers innumerable applications whether in the genetic monitoring cells in hereditary diseases, in pathogenic process infectious diseases, metabolic disorders and tumors or in the Decryption of natural processes Major such as embryonic development, molecular mechanisms and host-microbe interactions.
The integration of organoid technology with artificial intelligence and fluidic micro has accelerated the processes for the evaluation of toxicity and the effectiveness of drugs but also the progress of precision medicine. Combined with new high performance materials, 3D printing technology and gene editing, organoids take an equally central place in the field of regenerative medicine.
The fine and historical analysis of the origins and characteristics of the main types of organoids, as well as that of their very rapid evolution reveals
the great challenges that remain,
In particular problems related to standardization, contamination of matrix gels, bioethics and the complexity of the organs themselves. The main methods used in the construction of organoids which are increasingly benefiting from bio-engineering are also constantly evolving whether in research or in therapeutic applications.
There are therefore limits to be repelled in the field of organoids, but are already taking shape for this growing field which perfectly illustrates sustainable research.
