The second week of the Israel-Iran war began with additional strikes targeting an Iranian nuclear research facility as Iran’s foreign minister issued a warning against the United States joining the conflict.

Early Saturday, smoke could be seen rising from an area near a mountain in Isfahan, where a local official said Israel had attacked the nuclear research facility in two waves.

the target was two centrifuge production sites, adn the attacks came on top of strikes on other centrifuge production sites elsewhere in recent days, according to an Israeli military official speaking on condition of anonymity under army guidelines to brief reporters. It was the second attack on isfahan,which was hit in the frist 24 hours of the war as part of Israel’s goal to destroy the Iranian nuclear programme.

Akbar salehi, Isfahan province’s deputy governor for security affairs, confirmed the Israeli strikes had caused damage to the facility but said there had been no human casualties.

Israel’s defense minister said Saturday that the military had also killed three senior iranian commanders in targeted attacks – including a commander of Iran’s paramilitary Revolutionary Guard who he said financed and armed Hamas in preparation for the Oct. 7, 2023, attack on Israel that sparked the 20-month-long war in Gaza.

Iran launched a new wave of drones and missiles at Israel but there were no immediate reports of significant damage, and the Israeli official called it a “small barrage” that was largely intercepted by Israel’s defenses.

The official said part of the reason that Iran’s overnight attack had been relatively small was that the military had been targeting its launchers and estimates it has now taken out more than 50% of them.

“We’ve been able to take out a large amount of their launchers, creating a bottleneck – we’re making it harder for them to fire toward Israel,” he said. “Having said all that, I want to say the Iranian regime obviously still has capabilities.”

A spokesperson for the U.S. State Department confirmed to CBS News on Saturday that several U.S. citizens were “lightly wounded as an inevitable result of the impact of an Iranian missile strike.”

“Due to privacy considerations, we have no additional details at this time,” the spokesperson said.”If U.S. citizens in Israel and the West bank need emergency assistance,they should contact our Embassy in Jerusalem.”

Meanwhile, two flights departed from Tel Aviv to Athens Saturday with approximately 70 U.S. citizens, their accompanying immediate family members and lawful permanent residents, the State Department said, as the U.S.begins assisting with evacuations of Americans and green card holders.

U.S. B-2 stealth bombers heading to Guam

President Trump continues to consider whether the U.S. will militarily intervene in the Israel-Iran war, as he faces pressure from some world leaders to find a diplomatic solution. he said earlier this week that he will decide within two weeks if the U.S.will get involved in the conflict. The timeframe, some American and European officials say, is a “last sho