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Researchers from the University of Edinburgh in Scotland have discovered an accumulation of beta-amyloid toxic protein in the brain of dementia cats, one of the main characteristics of Alzheimer’s disease in humans.
This accumulation occurs in particular at the level of synapses, the junctions of the brain cells, essential to the proper functioning of the brain, according to their study.
This discovery could open up new perspectives in research on this neurodegenerative disease.
Why is this discovery so important?
As in humans, elderly cats often develop dementia which manifests itself by behavioral changes, symptoms strangely recalling those observed in people with Alzheimer’s. ::
- More frequent cries (meowing in this case);
- Confusion;
- Sleep disorders.
To achieve these observations, the research team examined the brain of 25 cats of different ages, some of which had signs of dementia. Thanks to advanced microscopy techniques, they were able to observe in detail the cellular changes.
Cats naturally develop dementia
Main advantage of this work: unlike genetically modified rodents commonly used in research on Alzheimer’s, cats naturally develop dementia. This makes it a more precise model to study the disease. Also, for Dr. Robert McGeachan, main author of the study, “these striking similarities between feline dementia and Alzheimer’s disease in humans open the door to exploring new promising treatments who could benefit both humans and our aging pets. »»
Thus, according to the authors, this discovery “will be a precious asset for cats, their owners, people with Alzheimer’s disease and their loved ones. Feline dementia is the ideal natural model for Alzheimer’s disease, and everyone will benefit. »»
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