Like in a big city. In our body, if waste collection is blocked, they accumulate. If failure to cleanse affects the nerve cells, obviously, there can be repercussions. So what? Then it is better to rely on those who, naturally, help some neurons eliminate the tau protein, linked to Alzheimer’s disease and other neurodegenerative diseases.
The “scavenger” protein is produced following instructions present in DNA, linked to a gene which, in turn, stimulates the production of a sort of invisible protein “label” (CRL5SOCS4) for tau.
Thanks to molecular “tags”, therefore, the harmful protein is directed to the cell’s waste disposal system for degradation and elimination.
The mechanism works only in some neurons, which survive longer than others. and in the future this protein could become a target for new targeted therapies against the “fog” that progressively pervades the brain in the case of Alzheimer’s disease, also linked to number protein.
Research published in Cell (first author) suggests this path, also identifying other invisible mechanisms of neuronal “cleaning”. Avi Samelson) and conducted by the experts ofUniversity of California Los Angeles and San Francisco (Usa).
