Seeking a Postdoctoral Fellow to Investigate Zika Virus Transmission Mechanisms

The Institut Pasteur is seeking a highly motivated postdoctoral fellow to join a collaborative project focused on understanding the intricate mechanisms driving Zika virus (ZIKV) transmission. This research initiative brings together the expertise of the Mouse Genetics Laboratory and the Insect-Virus Interactions Unit to explore the interplay between host genetics, viral strains, and mosquito vectors in ZIKV transmission.

Deciphering the Role of Host Genetics in Zika Virus Transmission

This postdoctoral position offers a unique opportunity to delve into the role of host genetic determinants in ZIKV transmission. The project leverages established experimental systems to investigate the dynamics of ZIKV infection in mouse models and during virus transmission between mosquitoes and mammalian hosts. the ultimate goal is to pinpoint specific host genes and mechanisms that influence variations in host-vector transmission, a critical aspect of public health.

Previous research has highlighted significant variations in clinical severity, plasma viral load, and neurological alterations among different mouse strains infected with ZIKV. Similarly, variations in transmissibility have been observed between different ZIKV strains and among diverse mosquito populations. This project aims to integrate these findings to provide a extensive understanding of ZIKV transmission dynamics.

The project aims at characterizing the mechanisms underlying the transmission of Zika virus using an integrated approach that considers genetic variation in the host, the virus and the mosquito vector.

Essential Qualifications and Desired Skills

Ideal candidates should possess a strong foundation in mouse models and virology,both conceptually and experimentally. Prior experience in mouse genetics and infection models is highly desirable. The prosperous candidate will be a collaborative team player with excellent communication skills in English and a strong sense of team spirit. A Ph.D. in genetics or virology is required, along with at least one first-author publication.

A Collaborative Research Environment at the Institut pasteur

The postdoctoral fellow will be based in the Mouse Genetics Laboratory, affiliated with the Genomes and Genetics and Virology Departments of the Institut Pasteur, and will work closely with the Insect-Virus Interactions Unit. The Institut Pasteur provides a dynamic and multidisciplinary research environment, offering access to cutting-edge technological platforms, including BSL-3 facilities.

The Mouse Genetics Laboratory boasts extensive expertise in viral infections and genetic analysis in mice, while the Insect-Virus Interactions Unit specializes in viral infections, entomology, and genetic analysis in mosquitoes. This collaborative environment fosters innovation and provides ample opportunities for professional growth.

Position Details and Request Information

The position is available promptly for a period of 24 months, with the possibility of extension up to 30 months depending on the start date. Salary will be commensurate with experience and in accordance with Institut Pasteur standards.

interested candidates are encouraged to submit their applications to caroline.manet[at]pasteur.fr. Applications should include a cover letter outlining your interest in the position and how your skills align with the job description,a detailed CV,a brief (1-page) description of your previous research,a list of publications,and contact information for at least two references.