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Urolithin A Investigated for Sleep Quality Improvement in New clinical Trial
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By Imani jefferson | LONDON – 2025/06/23 03:28:34
Urolithin A, a metabolite derived from natural polyphenols, is gaining recognition in anti-aging research for its role in regulating cellular metabolism.
A second clinical study has been launched to assess Urolithin A’s impact on sleep quality among middle-aged and older adults.This follows an earlier trial focusing on oral cosmeceutical applications. The new quadruple-blind, randomized study will explore Urolithin A’s potential to improve fragmented sleep and circadian rhythm disruptions, while also evaluating its broader anti-aging effects through biomarker analysis.
The trial aims to determine if Urolithin A can address sleep fragmentation and circadian disruption, while also confirming its complete anti-aging benefits via biomarker monitoring.
The Impact of Modern Lifestyles on Sleep and Aging
Globally, between 30% and 35% of adults experience sleep disorders.Modern lifestyles, characterized by late work hours, fragmented entertainment, and irregular sleep schedules, are contributing to widespread sleep deprivation. This sleep deprivation can accelerate aging at the cellular, organ, and systemic levels.
The Science Behind Sleep Disruption
“The resulting sleep deprivation is accelerating ageing process at cellular, organ and systemic levels, acting as a ‘silent killer’.”
Fragmented sleep, circadian rhythm disruption, menopausal hormonal changes, and mood disorders all contribute to sleep disturbances.
- Fragmented Sleep: frequent awakenings lead to light, non-continuous sleep, affecting cellular metabolism, promoting senescent cell accumulation, and increasing susceptibility to metabolic syndrome.
- Circadian Disruption: Exposure to artificial light and irregular schedules disrupt the body’s natural sleep-wake cycle, impacting clock gene regulation, exacerbating inflammation, and disrupting NAD+ metabolism.
- Menopausal Sleep Disorders: Estrogen withdrawal during menopause can down-regulate GABA transporters, increasing nighttime awakening risk, and vasomotor symptoms like hot flashes can disrupt sleep.
- Mood-Sleep cycle: Anxiety and depression are linked to sleep disturbances through cortisol rhythm disruption and serotonin dysregulation.
Frequently Asked Questions
What is Urolithin A?
Urolithin A is a metabolite produced in the gut after consuming foods containing ellagitannins, such as pomegranates.It is indeed being studied for its potential anti-aging and health-promoting properties.
How does fragmented sleep affect health?
Fragmented sleep can disrupt cellular metabolism, promote the accumulation of senescent cells, and increase the risk of metabolic syndrome.
What are circadian rhythms?
Circadian rhythms are the body’s internal 24-hour clock that regulates sleep-wake cycles and other physiological processes.
