PTE20250507004 in life
Combine therapy of the University of Oxford, even the most resistant bacteria destroys highly effective
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Bioscientist Eleanor Stride makes bacteria in bold (photo: ox.ac.uk) |
Oxford (pte004/07.05.2025/06:15)
Biotechnicians and doctors from the University of Oxford have developed a technique with which you can break through the biofilm barrier of bacteria so that antibiotics can start their attacks effectively.
Problematic dosage
“Bi -films are very difficult to penetrate. You would have to destroy them mechanically, which is hardly feasible in the body,” said expert Eleanor Stride. So far, the only way to use antibiotics in extreme doses. However, this does not always help and reinforce the resistance, so that the bacteria became even more resistant.
The solution consists in antibiotic nanoparticles that are activated precisely on the herds of infection. They are constructed in such a way that they quickly vaporize when ultrasound is being influenced. This has a double effect: the steam physically destroys the biofilm matrix and at the same time releases antibiotics directly at the stove of the infection.
Ultrasound penetrates deeply into the body, so that infections in areas that normally require a surgical intervention can be treated non-invasively. Healthy tissue is not destroyed, the scientists illustrate.
Antibiotics requirement reduced
The developers tested the nanoparticles on ten clinical bacterial strains, including E. coli and methicillin-resistant staphylococcus aureus and four antibiotics administered. The results were impressive. By combining nanoparticles and ultrasound, the antibiotic concentration in bacteria, which did not form biofilms, could be reduced by more than ten times compared to conventional treatment.
The steam has weakened the microorganisms so much that they better addressed the medication. With biofilm infections, the results were even more impressive. The combination of nanoparticles and ultrasound reduced the required antibiotic concentration by more than 40 times and eliminated 100 percent of the bacteria in clinically compatible doses.
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