According to initial studies, the inhibitory substance reduces the biofilm deposits on the teeth by around 25 percent, and the bacterial activity of these biofilms also decreases. According to the researchers, the pathogen can also inhibit the penetration of Porphyromonas gingivalis into the gum tissue and also reduce inflammatory markers.
From active ingredient to toothpaste
But a lot of work was still needed to develop the substance into an effective and market-ready toothpaste. The product must block the unwanted germs, but must not be toxic. It must not be absorbed by the organism and enter the blood, nor should it cause discoloration on the teeth. In order to carry out these studies and finalize the toothpaste, some Fraunhofer researchers founded the company PerioTrap Pharmaceuticals in 2018.
The PerioTrap toothpaste has since been created in close collaboration with the Fraunhofer IZI and the Fraunhofer Institute for Microstructure of Materials and Systems IMWS. “The product is used to prevent periodontitis. Like a normal toothpaste, it also contains cleaning agents and fluoride to prevent tooth decay,” explains Mirko Buchholz, one of the founders of the Fraunhofer spin-off. Schilling adds: “We have not simply developed a good toothpaste with a new substance, but rather a high-quality dental care product of medical quality.”
Care gel and mouthwash should follow
But the researchers’ work continues. They have already developed a care gel for use in the dental practice, which is applied after professional teeth cleaning. It blocks pathogenic bacteria, stabilizes the oral flora and keeps the gums healthy. The scientists are also currently working on developing a mouthwash with the periodontitis-inhibiting substance.
Even pets could benefit from this special dental care in the future. Since periodontal disease has very similar causes in dogs and cats, products for the care of pets are also on the agenda.
Source: Fraunhofer Society
January 6, 2026 – Nadja Podbregar
