Since spermidin was first discovered in the semen, it is named in many creatures from plants to bacteria. Many of us may be the first time we hear the name but Leslie Kenny, the founder of Oxford Health SPAN “Spermidin is the Swiss knife of long life” with his words, he draws attention to the benefits of spermide.
The benefits of spermide, which are good for many things from hair growth to heart health, do not stop counting.
Studies show that spermid, a naturally formed compound, can improve brain health, immunity, cardiovascular strength and overall appearance.
Spermidine found in foods such as breast milk, wheat seeds, soybeans, mature cheese, mushrooms and peas plays a key role in slowing aging, protection against diseases, fighting inflammation and protecting metabolism.
So which foods have spermidin, can we get enough foods, what does the research on this issue say? We talked to Aytaç Montenegro Specialist in Internal Medicine.
Kenny, who struggled with autoimmune disorders and inflammatory rheumatism in his 30s, met Spermidine through researchers at Oxford University.
Speaking to the New York Post, Kenny said that the researches revealed that spermide can rejuvenate the immune system of the mice, and that if the immune system works, he could protect us from cancer, pathogens and autoimmune attacks and added:
“Chronic inflammation is associated with diabetes, heart disease and muscle pain, so reducing inflammation can provide various health benefits. Spermidine supplementation, alzheimer’s disease, which can lead to amyloid-beta and TAU can also clean toxic proteins such as TAU”
It provides hormonal balance
In a study conducted in 2023, spermidine was called “groundbreaking ında in terms of hormonal health and fertility, because the research showed that spermid increases egg quality in old mice.
The same study showed that spermid can help hormone balancing and kidnapping.
Spermidine supplementation of the field test subjects in almost all stress hormone cortisol level decreased significantly and the level of testosterone in male subjects increased by 50 %.
Kaynak: The New York Times
Kenny said, “If you don’t take out the garbage, nothing will work, and the brain is exactly the same,” Kenny said: Kenny said:
“In women, as well as progesterone, estrogen and testosterone hormones, hormone pioneers Dhea and Pregnenolone also increased. Some women have actually reported that urinary incontinence, the urgency of going to the toilet was significantly reduced.
Internal Medicine Specialist Aytaç Montenegro, spermide, regularly made the general cleaning in your home and said about his effects on aging:
“Spermidine revitalizes the autophage, the cell’s own cleaning service.
• Old, broken “items” (damaged proteins) are discarded.
• Decomposed “white goods” (tired mitochondria) are renewed.
• The “dust” (chronic low -level inflammation) accumulated at home decreases. The speed of aging may decrease.
In animal experiments, spermid groups lived longer and more “vigorous”.
The table in human studies is promising but cautious:
We cannot say, “It extends the lifetime for sure ;; However, there are signs that it can slow down age -related performance decrease. ”
Montenegro, He explained the effect of spermide with an example of daily life:
“Cleaning unnecessary files on your phone and thinking as opening a care mode that protects battery health. The device works more fluently; the same logic is true for the cell. Imagine the autophagic as a city where the garbage collects regularly. If the garbage accumulates, the traffic will lock, the smell increases.
This order:
• By reducing “protein garbage ında in the brain, it can create a protective floor against Alzheimer’s and Parkinson’s risk.
• Prevents vascular occlusion with age in the heart and balances energy production.
• Living in the liver, fatigue in the muscles, the pancreas can alleviate insulin resistance. “
However, the balance is important in cancer, spermidin can help to extract cancerous cells at an early stage, and in advanced tumors can sometimes use this system “in favor” stating that Montenegro, so the cancer history should be used with the supervision of physician stressed.
The lowest effective dose of spermid is one milligram a day, Kenny said that it is difficult to reach this level with only diet, it is difficult to get this amount from food sources, but the reinforcement is more cultivated and continued:“Still, I want people to turn to plants if they can, because the fiber is really valuable,” he said.
Supports hair growth and prevents hair whitening
The same fast cell regeneration provides direct benefit to hair, skin and nails. The natural color of our hair comes from melan. As we get older, we produce less melanin, so we produce less hair pigment. This leads to whitening of our hair over time. However, it keeps spermidin hair follicle longer at the growth stage of the hair life cycle, which makes the hair longer and less white.
Better brain function
In a study conducted in 2020, the supplement of the spermide was found to protect from cognitive regression, memory loss and aging motor disorders.
Source: New York Post
What is the difference between reinforcement spermidine and spermidine from food?
• Reinforcement, like a “measure of certain” capsules. You will get the same dose every day. It is practical and controlled.
• Food is “natural package program .. Spermidine comes with fiber, polyphenol, vitamins and minerals; This combination often has a better and better balanced effect.
Aytaç Montenegro’s suggestion as a physician to get our daily needs from food, to use supplements in case of need.
Montenegro explained the foods rich in spermidin and how to consume:
Main Resources:
• Fermante Foods: Pickle, matured cheeses.
• Full Grain: Whole wheat, rye, whole wheat products.
• Legumes: Chickpeas, lentils.
• Seeds and nuts: Sesame, tahini, sunflower seeds.
• Mushroom
Cooking suggestion: Avoid excessive heating; Better to be steam, sauté or less cooked alive. It is enough to see the trio of “fermented + full grain + legume” trio on most days of the week.
Liver fat that is not connected to alcohol
(NAFLD) NAFLD occurs with excessive fat accumulation in the liver of people who consume less alcohol or never consume. The primary cause is obesity with metabolic risk factors such as type 2 diabetes, high blood pressure, high cholesterol and obstructive sleep apnea.
“In pre -clinical experiments and animal experiments, it reverses the effects of spermidine naykh.” Kenny said he developed a metabolic function and seems to be lowering LDL, ie bad cholesterol.
Source: New York Post
What should be considered when considering the supplement of spermid?
• As age increases, the potential of benefit may increase.
• If you have a history of cancer or active treatment, always contact your oncologist.
• Physician control is required to interact with drugs, immunosuppressants, chemotherapies that affect MTOR.
• Tolerance may vary in those with restless bowel syndrome, SIBO, histamine sensitivity.
• Data is limited in pregnancy and breastfeeding; We don’t recommend routine.
• Care should be taken in kidney/liver diseases.
• First of all, it is rational to increase the dose according to the effect of starting with a 8–12 week low-medium dose.
What is the table for brain health and Alzheimer’s?
When autophagic works, the “protein deposits ın in the brain decrease; Nerve cells operate more regularly. In observational studies, memory and attention tests are better in the elderly, spermid -rich elderly; Stating that the risk of dementia is lower, Montenegro said that small clinical trials have seen healing signals in oral memory in mild cognitive disorder. Nevertheless, in the treatment of Alzheimer’s treatment, he added that there is a need for wider and long -term research to be “standard ..
How does spermidine affect the immune system?
Spermidine improves the “fuel economy ın of immune cells. Mitochondria operate more efficiently, and thanks to autophage, intracellular layout is preserved. This can help calm the chronic low dose of inflammation.
Aytaç Montenegro, When consumed with fermented foods, a positive picture can be seen in the intestinal barrier and microbiota balance, it said that it was not “foaming”, but it was to make fine tuning and tried to explain it with a daily example:
“It does not speed up, but it does not speed, but it makes the driving more balanced and economical.”
Montenegro finally gave a few examples of the studies on Spermedin:
Animal Studies: Life expectancy is prolonged in the groups of spermidin; The relaxation function of the heart and the health of mitochondria heal.
Observatory Human Data: Diets containing more spermidine are associated with lower risk of death and better heart health.
Small clinical trials: Verbal memory and healing signals in verbal memory and executive functions in individuals with elderly and mild cognitive disorder; The security profile is usually good.
The spermid alone is not a magic wand; But your cells “Cleaning and Maintenance” A strong helper that regulates routine. Just as gathering your home regularly makes life easier, spermidin can improve the cell order and make the age more comfortable
