Role of HB-EGF in Inflammatory Processes in Multiple Sclerosis: Study by FAU Researchers published in Nature Immunology
2024-02-26 16:36:00
As the Friedrich-Alexander University Erlangen-Nuremberg (FAU) explains in the following press release, astrocytes can contribute to inflammatory processes in the brain, but can also promote their resolution. A crucial factor in this process is the tissue-protecting and wound-healing protein HB-EGF. This is shown by neuroimmunologists from FAU and other universities in Germany, Sweden and the USA in a joint study. Their findings, which could lead to new therapeutic approaches for multiple sclerosis, for example, were published in the renowned journal “Nature Immunology”.
What causes autoimmune diseases of the central nervous system (CNS), such as multiple sclerosis (MS), and what mechanisms cause the disease to progress have not yet been sufficiently researched. Glial cells, certain cells in the CNS, including so-called astrocytes, are increasingly coming into focus. Astrocytes are an important component of the CNS and, among other things, contribute to the supply of nutrients to nerve cells.
Several studies have shown that astrocytes can significantly influence the course of inflammatory diseases of the CNS and promote MS. “It has only recently become clear that astrocytes not only maintain the inflammatory processes in the CNS, but can also contribute to their resolution,” says Prof.
Combatting Fatigue: Understanding, Causes, and Solutions for Feeling Tired Despite Adequate Sleep
2024-02-25 22:20:04
Despite following the recommended hours of sleep per night, many people wake up feeling tired. And studies conducted around the world confirm the existence of unexplained fatigue among adults, with a notable prevalence among women. This problem persists even in those who lead a healthy lifestyle. According to a meta-analysis last year that examined 91 studies across three continents, one in five adults worldwide experienced general fatigue for up to six months, despite having no underlying illness.
The challenge of defining and understanding fatigue complicates the search for solutions. Although drowsiness and fatigue are often confused, experts differentiate them in that fatigue encompasses physical, cognitive and emotional aspects.
“Physical, cognitive and emotional energies are intertwined. Each area tends to depend on the others. For example, low physical and biochemical energy production can trigger both “brain fog” and the suppression of a key switch in the brain called the hypothalamus. This switch not only controls sleep, but also hormonal function. Its function can decrease both after acute stress and after continued severe stress. This is one of the reasons why stress can trigger both insomnia and irritability when you are hungry,” Jacob Teitelbaum,
CHMP recommends approval of 10 new medicines
#CHMP #recommends #approval #medicines
The Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommends the approval of 10 medications at your February meeting, among whom are four orphans. In the list it appears Mistake (tofersen), a therapy by Biogen for the treatment of adult patients with amyotrophic lateral sclerosis (ALS). This medication is indicated for the treatment of adults with ALS who have a mutation in the superoxide dismutase 1 (SOD1) gene.
The next orphan drug to which the EMA technical body has given approval has been Filspari (esparsentan), developed by Vifor for the treatment of primary immunoglobulin A nephropathy. Voydeya (danicopan), an orphan developed by Alexion, becoming the first oral treatment against residual hemolytic anemia in patients with paroxysmal nocturnal hemoglobinuria. This medicine has received support through the EMA’s Priority Medicines (PRIME) programme, which provides early and strengthened scientific and regulatory support to promising medicines with the potential to address unmet medical needs. The last orphan to have received a positive opinion from the EMA technical committee has been Zynyz (retifanlimab), from Incyte, for the treatment of Merkel cell carcinoma.
Regarding the section of non-orphan drugs, there are two vaccines intended for active immunization against the H5N1 subtype of the influenza A virus.
a new flooring for the municipal gym
New Taraflex Flooring Inaugurated at Calci Municipal Gym
Calci, Italy – A big celebration took place yesterday at the ‘Magagnini’ municipal gym in Calci as the new Taraflex flooring was inaugurated before the debut in a prestigious regional tournament of the VBC Calci men’s Under17 team. The innovative material, considered the best on the market for creating playgrounds, was funded by the municipal administration with an investment of over 40 thousand euros.
The new flooring is designed to improve the quality standards of the sports facility in Piazzale Forino, benefiting both students and sports associations who use it. With high levels of safety, comfort, and protection, the Taraflex flooring also reduces the risk of injuries and abrasions due to its ability to cushion impacts.
The ribbon-cutting ceremony was led by Mayor Massimiliano Ghimenti, Deputy Mayor Valentina Ricotta, and Councilors Giovanni Sandroni and Anna Lupetti. Engineer Claudia Marchetti, responsible for the Public Works sector of the Municipality of Calci, was also present along with top management of the VBC Calci and a warm and supportive audience.
Mayor Ghimenti expressed his satisfaction with the new addition to the gym, stating that sports facilities are crucial for the growth of young individuals and the municipality is proud to provide an up-to-date and welcoming space for the community.
Unanswered Questions: The Connection Between Weight Loss Medications and Eating Disorders
Eating Disorders and Weight Loss Medications
Researchers have raised concerns about the potential impact of popular weight loss medications on individuals with eating disorders. The lack of studies in this area has left many unanswered questions and could have serious consequences for those affected.
- GLP-1 Agonists for Weight Loss: Semaglutide, a medication originally prescribed for diabetes, has gained popularity as a weight loss treatment. However, experts worry about the potential effects of these medications on eating disorders.
- The Concerns: Dr. Aaron Keshen noted an increase in individuals with new or worsening eating disorder symptoms after being prescribed GLP-1 agonists. Eating disorders affect nearly 1 in 10 people in the United States and have a high crude mortality rate among mental illnesses.
- Lack of Research: Dr. Susan McElroy emphasizes that research on the connection between eating disorders and weight loss medications is limited. More studies are needed to provide clarity and guidance in prescribing these medications.
The Complexity of Eating Disorders
Eating disorders are complex biopsychosocial illnesses that can be triggered by various factors, including restricted food intake, weight loss, and societal pressures related to body image. Health care providers must screen patients for a history or vulnerability to an eating disorder before prescribing weight loss medications.
Combining Exercise with Weight Loss Drugs Improves Long-Term Results, Study Finds
Combining Exercise with Weight Loss Drugs Improves Long-Term Results, Study Finds
Weight loss drugs have been making waves in the pharmaceutical market, with medications like Ozempic and Wegovy gaining popularity. However, concerns have been raised about the long-term benefits of these drugs. Many individuals tend to regain a significant amount of weight once they stop taking these appetite-suppressing medications. But a recent study conducted by experts at the University of Copenhagen in Denmark has found a potential solution – combining weight loss drugs with supervised exercise programs.
The study focused on liraglutide, a drug that belongs to the same class as Ozempic and Wegovy. All these medications are known as glucagon-like peptide-1 (GLP-1) receptor agonists and were initially developed to treat diabetes. They work by mimicking a natural hormone in the body that controls blood sugar. However, researchers are still exploring how to best utilize the appetite-suppressing properties of these drugs for controlled weight loss.
According to biomedical scientist Simon Birk Kjær Jensen from the University of Copenhagen, people who stop taking weight loss drugs often struggle to maintain the positive effects. However, the study conducted by Jensen and his team reveals that individuals who incorporate exercise into their treatment have a better chance of sustaining weight loss even after stopping the drugs.
When do you start to lose your memory? Foods to improve mental health in adults | Health | Magazine
And forgot It can be something normal and even a funny story to tell your friends, leaving a comment related to how it is a sign of aging.
In the middle age of life this situation goes unnoticed. However, when it comes to an older adult, we must be careful that it is not a sÃntoma del Alzheimer.
When do you start to lose your memory?
According to the University Hospitals of Colombia and Cornell, when someone does not remember where they left their wallet it is considered forgetfulness, and it is something that is experienced as one ages; However, when these are repetitive on a daily basis, many aspects of life are affected and therefore it is a cause for concern.
Signs that someone is losing memory include:
1. Repeat the same phrases, questions or stories in the same conversation.
2. You don’t remember how to do tasks you do routinely, like brushing your teeth.
3. Forgetting those routine things that happen during the day, such as not remembering what medicine you took in the morning.
4. Feeling confused about what day of the week is.
Uncovering the Truth: Benefits and Risks of Common Dietary Supplements
- February 26, 2024
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This is how you can get rid of the causes of bad breath 2024-02-25 21:32:09
Magomed Dakhkilgov, implant surgeon, periodontologist and head doctor of the German Implant Center clinic, said that bad hygiene is the main cause of bad breath.
Publika.az reports that in a conversation with Lenta.ru, he listed the available methods to get rid of halitosis.
Dakhkilgov said that in most cases, the solution to bad breath is regular professional cleaning at the dentist’s office and compliance with all home hygiene rules. Teeth should be brushed twice a day for two to three minutes with an individually selected toothbrush and toothpaste.
The expert said that the fact that the teeth cannot be restored with either a filling or a crown also causes an unpleasant smell. According to the doctor, only tooth extraction can help in this case as a source of infection and inflammation.
Dakhkilgov also emphasized that inflammation of the oral cavity can occur not only due to dental problems, but also due to diseases of the oral cavity. In some cases, these can be purulent cysts that are released through a fistula in the gums. In such a situation, a doctor’s intervention is mandatory.
“Besides the known dental causes, there are also some that are not obvious.