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The Lancet Commission on rethinking coronary artery disease: moving from ischaemia to atheroma1 compellingly reframes coronary artery disease as a lifelong continuum, advocating for early prevention strategies rooted in atheroma detection. The Commission’s thoughtful and forward-looking reframing of atherosclerotic coronary artery disease (ACAD) as a systemic, lifelong condition marks a major and much-needed shift in cardiovascular care. The emphasis on early detection, risk factor modification, and the life-course approach is commendable and timely.
