Levothyroxine and Bone Loss in Older Adults: A Cause for Concern?
Levothyroxine, a common medication for hypothyroidism (underactive thyroid), might be linked to increased bone loss in older adults, even when thyroid-stimulating hormone (TSH) levels are within the normal range. This is a concerning finding, especially considering levothyroxine is the second most prescribed drug for older adults in the U.S.
Levothyroxine: Benefits and Potential Risks
Levothyroxine is a synthetic form of the thyroid hormone thyroxine (T4) and effectively treats hypothyroidism by replacing the hormone that the body isn’t producing enough of. Symptoms of hypothyroidism include fatigue, weight gain, hair loss, and more severe complications if left untreated.
However, a recent study presented at the Radiological Society of North America (RSNA) annual meeting suggests that long-term levothyroxine use may be associated with increased bone loss in older adults with normal thyroid function (euthyroidism).
“Our study suggests that even when following current guidelines, levothyroxine use appears to be associated with greater bone loss in older adults,” said Shadpour Demehri, M.D., co-senior author and professor of radiology at Johns Hopkins.
Study Details and Findings
The study, conducted by researchers at Johns Hopkins University School of Medicine, analyzed data from the Baltimore Longitudinal Study of Aging (BLSA). They compared bone loss in older adults taking levothyroxine (treated group) to those who were not taking the medication (control group). The study found that even with normal TSH levels, levothyroxine users experienced greater bone loss over time.
Discussion and Recommendations
While levothyroxine is a vital medication for many, these findings highlight the need for careful consideration of its potential long-term effects.
Dr. Jennifer Mammen, M.D., Ph.D., co-senior author and associate professor of endocrinology at Johns Hopkins, advises that adults taking levothyroxine should discuss their treatment with their healthcare provider and regularly monitor their thyroid function tests.
“A risk-benefit assessment should be conducted, weighing the strength of the indications for treatment against the potential adverse effects of levothyroxine in this population,” she said.
This research underscores the importance of ongoing monitoring and personalized treatment plans for older adults taking levothyroxine. It is a crucial step in balancing the benefits of thyroid hormone regulation with potential risks to bone health.
Talk to Your Doctor
If you take levothyroxine or have concerns about thyroid health, consult your doctor for personalized advice and monitoring.
