Chisholm-Burns, M., Kelly, B. S. & Spivey, C. A. Xenotransplantation could either be a friend or foe of healthcare equity. Commun. With. (Lond.) 485 (2024).
Google Scholar
Mohiuddin, M. M. et al. Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report. Lancet 402397–410 (2023).
Google Scholar
Mallapaty, S. & Kozlov, M. First pig kidney transplant in a person: what it means for the future. Nature 62813–14 (2024).
Google Scholar
Wang, Y. et al. Pig-to-human kidney xenotransplants using genetically modified minipigs. Cell rep. With. 5101744 (2024).
Google Scholar
Burdorf, L. et al. Pig-to-baboon lung xenotransplantation: extended survival with targeted genetic modifications and pharmacologic treatments. Am. J. Transplant. 2228–45 (2022).
Google Scholar
Li, Q. et al. Carbohydrate antigen expression and anti-pig antibodies in New World capuchin monkeys: relevance to studies of xenotransplantation. Xenotransplantation 26e12498 (2019).
Google Scholar
Bailey, J., Capaldo, T., Conlee, K., Thew, M. & Pippin, J. Experimental use of nonhuman primates is not a simple problem. Night. With. 141011–1012 (2008).
Google Scholar
Bharat, A. & Kreisel, D. Immunopathogenesis of primary graft dysfunction after lung transplantation. Ann. Thorac. Surg. 105671–674 (2018).
Google Scholar
Kubicki, N., Laird, C., Burdorf, L., Pierson, R. N. 3rd & Azimzadeh, A. M. Current status of pig lung xenotransplantation. Int J. Surg. 23247–254 (2015).
Google Scholar
Harris, D. G. et al. Lung xenotransplantation: recent progress and current status. Xenotransplantation 21496–506 (2014).
Google Scholar
Pullen, L. C. Xenotransplantation moves toward clinical trials. Am. J. Transplant. 24509–511 (2024).
Google Scholar
Whitsett, J. A. & Alenghat, T. Respiratory epithelial cells orchestrate pulmonary innate immunity. Nat. Immunol. 1627–35 (2015).
Google Scholar
Griffith, B. P. et al. Transplantation of a genetically modified porcine heart into a live human. Night. With. 31589–598 (2025).
Google Scholar
Snell, G. I. et al. Report of the ISHLT Working Group on Primary Lung Graft Dysfunction, part I: definition and grading – a 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation. J. Heart Lung Transplant. 361097–1103 (2017).
Google Scholar
Montgomery, R. A. et al. Results of two cases of pig-to-human kidney xenotransplantation. N. Engl. J. Med. 3861889–1898 (2022).
Google Scholar
Burdorf, L. et al. Thromboxane and histamine mediate PVR elevation during xenogeneic pig lung perfusion with human blood. Xenotransplantation 26e12458 (2019).
Google Scholar
Loupy, A. et al. Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study. Lancet 4021158–1169 (2023).
Google Scholar
Estrada, J. L. et al. Evaluation of human and non-human primate antibody binding to pig cells lacking GGTA1/CMAH/beta4GalNT2 genes. Xenotransplantation 22194–202 (2015).
Google Scholar
Anand, R. P. et al. Design and testing of a humanized porcine donor for xenotransplantation. Nature 622393–401 (2023).
Google Scholar
Xu, H., Perez, S. D., Cheeseman, J., Mehta, A. K. & Kirk, A. D. The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation. Am. J. Transplant. 14319–332 (2014).
Google Scholar
Mavragani, C. P. Mechanisms and new strategies for primary Sjogren’s syndrome. Annu. Reef. With. 68331–343 (2017).
Google Scholar
Moazami, N. et al. Pig-to-human heart xenotransplantation in two recently deceased human recipients. Night. With. 291989–1997 (2023).
Google Scholar
Chen, J. Q. et al. Scan of the endogenous retrovirus sequences across the swine genome and survey of their copy number variation and sequence diversity among various Chinese and Western pig breeds. Zool. Res. 43423–441 (2022).
Google Scholar
Chen, S. Ultrafast one-pass FASTQ data preprocessing, quality control, and deduplication using fastp. Achieve 2e107 (2023).
Google Scholar
Langmead, B. & Salzberg, S. L. Fast gapped-read alignment with Bowtie 2. Nat. Methods 9357–359 (2012).
Google Scholar
Menown, I. B., Archbold, J. A., Bamford, K. B., Bell, P. M. & Callender, M. E. Community-acquired lower respiratory tract infection: implementation of an antibiotic protocol. Br. J. Clin. Pract. 5174–77 (1997).
Google Scholar
Houtgast, E. J., Sima, V. M., Bertels, K. & Al-Ars, Z. Hardware acceleration of BWA-MEM genomic short read mapping for longer read lengths. Comput. Biol. Chem. 7554–64 (2018).
Google Scholar
Goodacre, N., Aljanahi, A., Nandakumar, S., Mikailov, M. & Khan, A. S. A reference viral database (RVDB) to enhance bioinformatics analysis of high-throughput sequencing for novel virus detection. mSphere 3e00069–18 (2018).
Google Scholar
Kim, D., Paggi, J. M., Park, C., Bennett, C. & Salzberg, S. L. Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype. Nat. Biotechnol. 37907–915 (2019).
Google Scholar
Liao, Y., Smyth, G. K. & Shi, W. featureCounts: an efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics 30923–930 (2014).
Google Scholar
