A Novel Delivery System for a Familiar Molecule

A new formulation of finasteride,the widely used treatment for mild to moderate androgenetic alopecia (male pattern baldness),has become available in French pharmacies. Dubbed “Fincrezo,” this innovative product distinguishes itself through its topical application, offering a potentially more targeted approach to hair loss management.

Unlike conventional oral finasteride, Fincrezo is applied directly to the scalp in areas experiencing hair thinning. The recommended dosage involves one to four daily sprays, allowing for localized treatment.

Targeted Treatment, Reduced Systemic Exposure

Produced by the Bailleul laboratory, Fincrezo represents the first finasteride-based treatment administered topically. This delivery method is designed to minimize the drug’s systemic circulation, potentially reducing the risk of side effects associated with oral finasteride. According to Specialized Pharma365, topical application results in approximately 100 times less exposure to the molecule throughout the body.

This localized approach could be particularly appealing to individuals concerned about the potential systemic side effects of oral finasteride, which, while generally uncommon, can include sexual dysfunction and mood changes.

Understanding the Risks: Psychiatric and Sexual Side Effects

While finasteride has proven effective for many, it’s crucial to acknowledge the potential risks. the ANSM (National Agency for Medicines Safety) issued a notice in 2019, updated in October 2024, highlighting the risks of psychiatric and sexual side effects associated with finasteride use. This advisory emphasizes the importance of patient awareness and careful monitoring during treatment.

Symptoms and psychiatric disorders such as anxiety, mood changes, in particular depressed mood, depression and less frequently suicidal thoughts, were observed during and after the use of the finasteride.

National Agency for Medicines Safety (ANSM)

The ANSM advises immediate treatment interruption if psychiatric disorders develop. Similarly, sexual side effects like erectile dysfunction or decreased libido warrant discontinuation, even though these issues may persist after stopping the medication.

The Broader Context of Hair Loss Treatments

The introduction of topical finasteride adds another option to the growing market of hair loss treatments. According to the International Society of Hair Restoration Surgery (ISHRS), the hair restoration industry is a multi-billion dollar market, reflecting the significant demand for effective solutions.While finasteride remains a cornerstone of treatment, othre options include minoxidil, hair transplantation, and laser therapy.

The availability of Fincrezo in France marks a significant growth in the field, offering a potentially safer and more targeted approach to combating hair loss. However, as with any medication, it’s essential to consult with a healthcare professional to determine the most appropriate treatment plan and to understand the potential risks and benefits.