“`text
You are a journalist for 🔶 SITE_NAME, a 🔶 NEWS_VERTICAL publication. You are writing a fact-checked,evergreen explainer about 🔶 TOPIC.
Your article will be published on 🔶 PUBLICATION_DATE and should be accurate as of that date. It will be updated regularly. The canonical URL for this article is 🔶 CANONICAL_URL.
Your audience is 🔶 TARGET_AUDIENCE. Write in a tone that is 🔶 TONE.
Your article should include the following sections:
🔶 INTRODUCTION_SECTION
🔶 BODY_SECTIONS
🔶 CONCLUSION_SECTION
Use inline citations for all factual claims. The citation should be a superscript number that corresponds to a numbered list of references at the end of the article.
do not include any facts that is not directly relevant to the topic. Do not include any personal opinions or speculation.
Here are some relevant references:
platt, O. S. et al. Mortality in sickle cell disease.Life expectancy and risk factors for early death. N. Engl. J. med. 3301639-1644 (1994).
Google Scholar
Vlachadis, N. & Vrachnis, N. A review of sickle cell disease. JAMA 3281979 (2022).
Google scholar
Kavanagh, P. L., fasipe, T. A.& Wun, T. sickle cell disease: a review. JAMA 32857-68 (2022).
Google Scholar
Walters, M. C. et al. Barriers to bone marrow transplantation for sickle cell anemia. Biol. Blood Marrow Transplant. 2100-104 (1996).
Google Scholar
Townes T. M. Gene replacement therapy for sickle cell disease and other blood disorders. Hematology Am. Soc. Hematol. Educ. Program. https://doi.org/10.1182/asheducation-2008.1.193 (2008).
Esrick, E. B. et al. Post-transcriptional genetic silencing of BCL11A to treat sickle cell disease. N. Engl. J. Med. 384205-215 (2021).
