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Adipokine Hypothesis Offers New understanding of Heart Failure with Preserved Ejection Fraction
A novel hypothesis suggests that changes in internal fat tissue might potentially be a key factor in the development of HFpEF.
A new outlook on heart failure with preserved ejection fraction (hfpef) has emerged with the Adipokine Hypothesis, suggesting that alterations in the biology of internal fat tissue play a important role in the condition. The hypothesis, detailed in a paper published in the *Journal of the American College of Cardiology (JACC)* and presented at ESC Congress 2025, proposes a new way to understand the impact of fat on the heart.
According to Milton Packer, MD, FACC, Distinguished Scholar in Cardiovascular Science at Baylor University Medical Center at Dallas and Visiting Professor at Imperial College in London, “up to now, there has been no unifying hypothesis to explain HFpEF.That has resulted in significant misunderstanding and a lack of direction in both diagnosis and therapy.This bold new framework helps to identify the true cause of HFpEF in most people. That should make an enormous difference in guiding effective treatments.”
hfpef, the most prevalent form of heart failure, affects approximately 4 million individuals in the united States and 32 million worldwide. In HFpEF, the heart muscle stiffens, hindering its ability to
