A new study published in Journal of Thrombosis and Haemostasis shows that Both genetic and lifestyle factors significantly influence the risk of blood clots formation in the lower limbs (deep venous thrombosis – TVP)a condition with lethal potential if not diagnosed and treated in time. Researchers at Lund University of Sweden analyzed the genetic and clinical data of 28,794 adults, participants in the population study „Malmö Diet and Cancer”. They examined 27 genes involved in blood coagulation and have identified three frequent genetic variants, in genes ABO, F8 and VWFassociated with an increased risk of venous thromboembolism (VTE).
Each of these genetic variants is correlated with an increase in the individual risk of clot formation between 10% and 30%. In people who had a larger cumulation of mutations (for example, five risk alleles), the risk was increased by up to 180%. These mutations are widespread in many populations globallywhich makes them useful for the genetic evaluation of the thrombotic risk in various geographical regions. The researchers have developed an scor genetic de risc Based on these three variants, which have a predictive accuracy similar to that of the factor V Leiden mutation, one of the most popular genetic causes of thrombosis.
The study has also analyzed physical and behavioral factors that can influence the formation of clots. High, overweight or sedentary people have a slower venous circulation in the lower limbswhich favors the venous stasis and triggering the coagulation process. Prolonged immobilization during long flights, hospitalizations or bed rest, is an important aggravating factor. During pregnancy, the levels of coagulation factors increase, while proteins with a protective role can decrease, which causes pregnant women to be exposed to a higher risk of thrombosis.
In terms of diet, data suggests that o healthy eatingrich in vegetable foods and acids Omega-3 fat can reduce the risk of thrombosis. Instead, frequent consumption of ultra -home foods seems associated with a slightly increased risk.
These findings open the way to personalized preventive measures. In situations with high risk (such as surgery, pregnancy, cancer or long trips), people with genetic predisposition may benefit from prophylaxis with anticoagulants. At the same time, Lifestyle changes: quitting smokingweight control, regular physical activity and balanced diet, remain essential for reducing the risk of thrombosis.
Read also:
