Disease Outbreaks 2025: US Impact & Global Risks

Disease Country Region* Primary Category for Disease/Transmission Number of Cases/Deaths (as of date) Acute febrile illness Democratic Republic of the Congo Sub-Saharan Africa Not applicable 1,318 suspected cases, inc. 53 deaths (as of Feb. 25) Anthrax Democratic Republic of the Congo Sub-Saharan Africa Direct contact infection 17 suspected cases, inc. 1 death (as of April 30) Thailand East Asia and the Pacific 5 confirmed cases, inc. 1 death (as of May 28) Uganda Sub-Saharan Africa 15 confirmed cases, inc. 2 deaths (as of March 30) Avian Influenza Cambodia East Asia and the Pacific Respiratory infection Cambodia: 11 confirmed cases, inc. 6 deaths (as of July 1)
Mexico: 1 confirmed case, inc. 1 death (as of April 2) Mexico Western Hemisphere Chapare hemorrhagic fever Bolivia Western Hemisphere Direct contact infection 1 confirmed case, inc. 1 death (as of Jan. 13) Chikungunya Key countries:
Bangladesh South and Central Asia Vector-borne infection Global overview: 445,271 (263,592 suspected and 181,679 confirmed) cases, inc. 155 deaths (as of Sept. 30)
Indian Ocean countries: data not provided (as of Sept. 5)
Bolivia: data not provided (as of June 26)
Cuba: data not provided (as of Sept. 26)
La Réunion and Mayotte (France): in La Réunion, over 47,500 confirmed cases, but more than 170,000 consultations for suspected chikungunya, and at least 12 deaths, with more suspected; in Mayotte, 116 cases (as of May 4) Bolivia Western Hemisphere China East Asia and the Pacific Cuba Western Hemisphere Kenya Sub-Saharan Africa Reunion and Mayotte (France) Sub-Saharan Africa Madagascar Sub-Saharan Africa Somalia Sub-Saharan Africa Sri Lanka South and Central Asia Cholera Afghanistan South and Central Asia Food-/waterborne infection Global overview: 489,452 cholera/Acute Watery Diarrhea cases; 6,155 deaths (as of Sept. 26; earlier alert) Angola Sub-Saharan Africa Bangladesh South and Central Asia Burundi Sub-Saharan Africa Chad Sub-Saharan Africa Ivory Coast Sub-Saharan Africa Democratic Republic of the Congo Sub-Saharan Africa Ethiopia Sub-Saharan Africa Ghana Sub-Saharan Africa Haiti Western Hemisphere India South and Central Asia Iraq Near East Kenya Sub-Saharan Africa Malawi Sub-Saharan Africa Mozambique Sub-Saharan Africa Myanmar East Asia and the Pacific Namibia Sub-Saharan Africa Nepal South and Central Asia Niger Sub-Saharan Africa Nigeria Sub-Saharan Africa Pakistan South and Central Asia Philippines East Asia and the Pacific Republic of the Congo Sub-Saharan Africa Rwanda Sub-Saharan Africa Somalia Sub-Saharan Africa South Sudan Sub-Saharan Africa Sudan Sub-Saharan Africa Tanzania Sub-Saharan Africa Thailand East Asia and the Pacific Togo Sub-Saharan Africa Uganda Sub-Saharan Africa Yemen Near East Zambia Sub-Saharan Africa Zimbabwe Sub-Saharan Africa Dengue United States of America Western Hemisphere Vector-borne infection Outbreaks in various areas (as of July 29); 2,560 locally acquired cases (as of Sept. 25) Ebola virus disease (EVD) (inc. Sudan virus diseaseSVD) Democratic Republic of the Congo

Uganda

Sub-Saharan Africa Direct contact infection EVD: 64 suspected (53 confirmed and 11 probable) cases, inc. 43 deaths (as of Oct. 5; earlier alert)

SVD: 14 cases – 12 confirmed, 2 probable – inc. 4 deaths – 2 confirmed, 2 probable (as of April 26)

Invasive meningococcal disease Saudi Arabia Near East Direct contact infection 17 cases (as of April 11) Marburg virus disease Tanzania Sub-Saharan Africa Direct contact infection 10 suspected (2 confirmed, 8 probable) cases, inc. 10 deaths (as of March 12) Measles Argentina Western Hemisphere Respiratory infection Region of the Americas (inc. United States of America): 10,139 confirmed cases, inc. 18 deaths (as of Aug. 8; earlier alert)
Morocco: more than 25,000 suspected cases, inc. 13,706 confirmed cases and 184 deaths, from Oct. 2023 through April 13, 2025 (as of May 13)
United States of America: 1,544 cases, inc. 3 deaths (as of Sept. 30) Belize Western Hemisphere Bolivia Western Hemisphere Brazil Western Hemisphere Canada Western Hemisphere Costa Rica Western Hemisphere Mexico Western Hemisphere Morocco Near East Paraguay Western Hemisphere Peru Western Hemisphere United States of America Western Hemisphere Middle East respiratory syndrome (MERS) coronavirus Saudi Arabia Near East Respiratory infection 9 confirmed cases, inc. 2 deaths (as of April 21) Mpox Key countries:
Burundi
Democratic Republic of the Congo
Kenya
Rwanda
Sierra Leone
Uganda Sub-Saharan Africa Direct contact infection Global overview: 38,671 confirmed cases, inc. 163 deaths (as of Aug. 31; earlier alert) Nipah virus Bangladesh
India South and Central Asia Direct contact infection Bangladesh: 4 confirmed cases, inc. 4 deaths (as of Aug. 29)
India: 4 confirmed cases, inc. 2 deaths (as of July 12) Oropouche virus disease Key countries:
Brazil
Panama Western Hemisphere Vector-borne infection Data not provided (as of July 14); Americas Region overview: 12,786 confirmed cases (as of July 27) Rabies Timor-Leste East Asia and the Pacific Direct contact infection 4 confirmed cases, inc. 4 deaths (as of June 17) Rift Valley Fever Senegal Sub-Saharan Africa Vector-borne infection Data not provided (as of Oct. 10) Variant Poliovirus (i.e., circulating vaccine-derived poliovirus of three types: cVDPV1, cVDPV2, cVDPV3) cVDPV1:
Algeria Near East Food-/waterborne infection cVDPV1 global overview: 2 cases of acute flaccid paralysis (as of Oct. 6)
cVDPV2 global overview: 146 cases of acute flaccid paralysis (as of Oct. 6)
cVDPV3 global overview: 5 cases of acute flaccid paralysis (as of Oct. 6) Democratic Republic of the Congo Sub-Saharan Africa cVDPV2:
Angola Sub-Saharan Africa Benin Sub-Saharan Africa Burkina Faso Sub-Saharan Africa Central African Republic Sub-Saharan Africa Chad Sub-Saharan Africa Djibouti Sub-Saharan Africa Ethiopia Sub-Saharan Africa Niger Sub-Saharan Africa Nigeria Sub-Saharan Africa Papua New Guinea East Asia and the Pacific Somalia Sub-Saharan Africa Sudan Sub-Saharan Africa Yemen Near East cVDPV3:
Cameroon Sub-Saharan Africa Chad Sub-Saharan Africa Guinea Sub-Saharan Africa Yellow fever Bolivia
Brazil
Colombia
Ecuador
Peru Western Hemisphere Vector-borne infection 235 confirmed cases, inc. 96 deaths (as of May 25; earlier alert) Zika virus disease India South and Central Asia Vector-borne infection 151 cases in 2024 (as of Jan. 29) Note: * Regions reflect those used by the U.S. State Department; Near East includes the Middle East and North Africa. Disease outbreaks as identified and defined by the following authoritative sources: WHO, CDC, and GPEI; not an exhaustive list of outbreaks globally. As of Oct. 10, 2025. Does not include diseases such as COVID-19, wild poliovirus, and seasonal influenza where there have not been unexpected levels of cases and deaths this year.

Sources: WHO, Disease Outbreak News, Situation Reportsand Rapid Risk Assessment Reports; CDC, Outbreak webpage; CDC, Travel Notices webpage;GPEI, Polio This Week.