Mlakar y collaborators show that, in individuals suffering from mental illness, caffeine consumption can produce a lengthening of telomeres that is interpreted as a ‘rejuvenation’ of some cinco years.
He job has been centered on individuals con schizophrenia o disorders affective recruited in Norway, of what these individuals present and shortening of los telomeres regard to the general population.
This study analyzes various factors in a population of individuals affected by mental illnesses who belong to a cohort that has been followed for several years between 2007 and 2018.. A cohort is a group of individuals selected for one or more reasons, generally the presence or absence of a disease, and who are studied periodically to learn how that disease evolves.
In this cohort, the size of telomeres isolated from white blood cells taken from a blood sample was analyzed and compared between groups that were created based on the daily consumption of cups of coffee between them. This comparison shows that those individuals with longer telomeres are also those who consume 4-5 cups of coffee, with caffeine, per day. And also, that greater consumption is not associated with greater telomere length. For this analysis, the authors have taken into account not only these two factors, coffee consumption and telomere length, but have also considered factors that may affect one or the other directly and indirectly. Likewise, they have not taken into account factors that may also influence these characteristics: physical activity, type of diet, consumption of medication for the disorders under study or other chronic problems that they may suffer from. This can affect both the tendency to consume more or less coffee and the length of the telomeres themselves.
The results of this study suggest that caffeine, at doses in the high range of what is considered healthy, about 400 mg/day, could have a positive effect by stopping the telomere shortening normally seen in these mental disorders. The existing evidence indicates that these disorders have a shortening of telomeres, which is also greater in the case of individuals with more severe manifestations.
In this study, other known factors that could have a role in telomere length have not been included, such as the degree of severity of the patients’ disease, the diet followed, the existence of sufficient physical activity, and exposure to environmental toxins (pollution, pesticides or others). This does not diminish the validity of the study, although it serves to contextualize the main finding.
Las reasons what do what people with these disorders have a minor length of his telomeres they are not clearly known. Besideshay what have in account what these studies with do on cells of the sangre and not they usually become on cells of the system highly strung what es where reside the base pathophysiological of these disorders.
By studies epidemiologicalif you know what some factors environmental son important at the time of accelerate/delay he shortening telomeric associated al aging: obesity, depression, exhibition a pesticides O LA LA pollution o he meet in situations of stress chronic, but los mechanisms what lo do they are not acquaintances.
Regarding mental illnesses, it has long been known that their lower life expectancy coincides with a shortening of their telomeres. Again, the reason for this association is not acquaintance.
Several studies show what in the general population he consumption up to 4-5 mugs of coffee, with caffeinenot up to date has effects negatives y, in function of the individual, can arrive to be positive. Now GOOD, this no implies what those effects with day a through of one elongation of los telomeres or of a decrease of are bowl of shortening. Hay what remember what he study is centered on a population whatof match, has some telomeres shortened y he study observa what he consumption of coffee associate with a increase of that size. Transfer this a situations different no can become sin fall in he risk of obtain conclusions no based in los data.
HThere are studies that show that healthy diets are associated with longer telomere length. Specifically, those who follow the Mediterranean diet have longer telomeres. Something similar is observed in diets based on the consumption of plant foods in which healthy ones (nuts, rich in fiber) are differentiated from less healthy ones where it is observed that the length of the telomeres is greater in the first case. But the situation is not so simple to understand. For example, in a study with a calorie-restricted diet, a Mediterranean-type diet, a slowdown in telomere shortening was observed, but only in women and not in men.
