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Physiological evaluation using fractional flow reserve (FFR) provides more accurate assessment of the haemodynamic significance of coronary artery stenosis than coronary angiography alone. FFR-guided percutaneous coronary intervention (PCI) results in better short-term and long-term outcomes than PCI guided by coronary angiography or medical therapy alone.1,2 Angiography-derived FFR is a way to estimate FFR from standard coronary angiography images using computational fluid dynamics or related algorithms, without passing a pressure wire or administering hyperaemic agents, with overall good correlation with invasive, wire-based FFR.
