BRAIN-AF: Stroke & Cognitive Decline Prevention in Atrial Fibrillation

by Archynetys Health Desk

Nature Medicine, Published online: 07 January 2026; doi:10.1038/s41591-025-04101-y

In a multicenter, randomized trial of patients with atrial fibrillation and a low risk of thromboembolic events, treatment with the anticoagulant rivaroxaban showed no benefit in reducing cognitive decline, stroke or transient ischemic attack when compared to placebo.

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