The suspicion that omeprazole could cause dementia or Alzheimer’s has been ruled out by recent peer-reviewed studies. Initial research, such as a German study published in 2014, had highlighted a possible association between prolonged use of proton pump inhibitors and a higher incidence of dementia. However, later work, such as the 2017 Finnish one in the journal Neurology, did not confirm this link.
According to neurologists and gastroenterologists, continuous use of omeprazole without medical supervision can generate other risks, such as vitamin B12, iron and magnesium deficiency, which indirectly affects brain metabolism. This deficiency can cause symptoms such as fatigue, memory lapses and difficulty concentrating, but it does not mean that the medication causes direct neurological damage.
Experts reinforce that omeprazole should be used for a specified period of time and with periodic medical reassessment. Prolonged use is related to gastrointestinal changes and nutrient reduction, but there is no scientific evidence that it causes Alzheimer’s. The guidance is clear: use the lowest dose possible, for as long as necessary, always under prescription and professional supervision.
