The San Francisco 49ers and Arizona Cardinals play on Sunday, Nov. 16, in a game on the NFL Week 11 schedule.
Here’s a look at the time, TV channel and broadcast information for the Week 11 NFL game, which will be played at the Cardinals’ State Farm Stadium.
The 49ers are a 2.5-point favorite over the Cardinals in NFL Week 11 odds for the game, courtesy of BetMGM Sportsbook. San Francisco is -150 on the moneyline, while Arizona is +125. The over/under (point total) is set at 48.5 points.
The Cardinals are coming off a 44-22 loss against the Seattle Seahawks in NFL Week 10. The 49ers lost to the Los Angeles Rams, 42-26.
Here’s how to watch the 49ers vs Cardinals game on television and how to stream the game on streaming services:
NFL Week 11 picks: Jets at Patriots | Commanders vs Dolphins | Panthers at Falcons | Buccaneers at Bills | Chargers at Jaguars | Bears at Vikings | Packers at Giants | Bengals at Steelers | Texans at Titans | 49ers at Cardinals | Seahawks at Rams | Ravens at Browns | Chiefs at Broncos | Lions at Eagles | Cowboys at Raiders | The Republic’s predictions
Watch 49ers at Cardinals on FUBO (free trial)
TV channel: FOX
Start time: 2:05 pm MST (Arizona), 4:05 pm ET
How to watch San Francisco 49ers vs Arizona Cardinals game on livestream
The game can be streamed on streaming services that carry FOX, including FUBO, which offers a free trial.
Who are the announcers for the San Francisco 49ers vs Arizona Cardinals NFL Week 11 game?
Kevin Kugler (play-by-play) and Daryl Johnston (analyst) are scheduled to be the announcers for the Cardinals vs 49ers Week 11 NFL game today.
Arizona Cardinals schedule 2025 (all times MST)
- NFL Week 11: Sunday, Nov. 16 vs. San Francisco 49ers, Fox, 2:05 p.m. (stream with FUBO)
- NFL Week 12: Sunday, Nov. 23 vs. Jacksonville Jaguars, CBS, 2:05 p.m. (stream with FUBO)
- NFL Week 13: Sunday, Nov. 30 at Tampa Bay Buccaneers, Fox, 11 a.m. (stream with FUBO)
- NFL Week 14: Sunday, Dec. 7 vs. Los Angeles Rams, Fox, 2:25 p.m. (stream with FUBO)
- NFL Week 15: Sunday, Dec. 14 at Houston Texans, Fox, 11 a.m. (stream with FUBO)
- NFL Week 16: Sunday, Dec. 21 vs. Atlanta Falcons, Fox, 2:05 p.m. (stream with FUBO)
- NFL Week 17: Saturday or Sunday, Dec. 27-28 at Cincinnati Bengals, TBD (stream with FUBO)
- NFL Week 18: Saturday or Sunday, Jan. 3-4 at Los Angeles Rams, TBD (stream with FUBO)

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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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