Translational research has a crucial role in healthcare by applying laboratory-based discoveries to practical patient-focused solutions. However, translational research often stalls due to obstacles that prevent the transfer of findings from the laboratory to the patient (from bench to bedside). Factors contributing to this inefficiency include misalignment of research goals between laboratory scientists and clinicians and a lack of support for the necessary infrastructure. Additionally, the challenges that early-career researchers (both laboratory and clinical researchers) face in navigating translational research, without dedicated mentorship and hands-on training, frequently go unnoticed. ‘Where do I even start?’ is a question often asked by early-career investigators.
Traditional laboratory frameworks in basic/fundamental science are often led by a principal investigator (PI) with a focus on a single disease or mechanism. These support and engage a narrow scope of investigation, rather than providing consultation for, and serving the needs of, investigators with multiple interests. In addition, the traditional PI-lab model sometimes carries the risk of generating discoveries without a clear pathway for clinical application, further expanding the gap between knowledge and implementation for improved patient outcomes.