It has become necessary to understand the structural changes occurring in… Pancreas During type 1 diabetes, this scientific understanding is an important step for developing new and effective drugs to combat the disease.
Scientific experiment on the pancreas
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Scientists from Novgorod University conducted a study to determine structural changes in the pancreas during type 1 diabetes. The results of the study were published on the university’s official website.
The study was led by anatomy pathologist Stanislav Senchugov, using laboratory mice of the Winstar strain. The animals were divided into two groups:
Control group
An experimental group was induced to develop diabetes
Several tests were conducted on animals, including:
Measure blood glucose level
Insulin measurement
Study of structural changes in the pancreas
Structural changes in the pancreas
The results showed that the islets of Langerhans, which are responsible for hormone production, underwent significant pathological changes. The percentage of loss of insulin-producing cells increased significantly, reaching 45% in the experimental group compared to 75% in the control group.
It was also observed that the blood glucose level increased by 4.5-fold, while the insulin level decreased significantly, with the maximum changes recorded during the first 10 days after diabetes stimulation.
Physical effects on mice
In addition to structural changes, affected mice experienced abnormalities in pancreatic cells and disruption of blood flow to the tissues. Weight loss in animals increased to 10%, and mortality rates increased to 40%.
The importance of the results
Researchers confirm that understanding the processes that occur in the pancreas during type 1 diabetes represents a basis for developing new and effective treatments that may reduce complications associated with diabetes and improve the quality of life of patients.