UNIST discovers neuroprotective gene that suppresses degenerative brain disease – Sciencetimes

Ulsan Institute of Science and Technology (UNIST) announced on the 30th that it has discovered a gene that suppresses degenerative brain diseases such as Lou Gehrig’s disease and frontotemporal dementia.

Lou Gehrig’s disease is a typical degenerative brain disease in which toxic proteins accumulate in cells and cause the death of nerve cells.

In the process of finding the gene that controls the cytotoxicity of ALS toxic protein, the team led by Professor Jeong-Hoon Lim of the Department of Life Sciences discovered a clue that the gene ‘ZNF598’ suppresses neuronal degeneration and verified it using various gene editing and control models. .

In particular, the professor’s team discovered that ribosome (a complex made up of ribonucleic acid and protein) stagnant when a toxic protein is translated (the process in which the basic structure is synthesized) through the technology developed in-house.

In other words, when a toxic protein is produced, the ribosome stops to decompose the toxic protein. At this time, ZNF598 recognizes that the ribosome has stopped and signals to quickly eliminate the toxic protein already made.

In conclusion, ZNF598 activation inhibits degenerative brain disease.

Ulsan Institute of Science and Technology expects this discovery to be a new breakthrough in the prediction, diagnosis and treatment of related diseases.

The results of this study were published in the online version of the ‘Journal of Nucleic Acid Research’ on September 22, an academic journal in the field of life science.

This research was carried out through the Gyeongbae Seo Science Foundation, the mid-level research support project of the National Research Foundation, the leading research center support project, and the biomedical technology development project.

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