Toei Shinyaku, which manufactures and sells supplements, recently announced that a new paper on the immune-related usefulness of the open-field agaricus “KA21 strain” has been published in an academic journal. As a result of human clinical trials, it was confirmed that even a low dose of 900 to 1500 milligrams per day exerts an effect of increasing the antibody titer against fungi (molds). The total number of international papers on KA21 shares has reached 31, which is the largest number among companies handling Agaricus.
Accumulate a wide range of evidence such as immunity and beauty
Agaricus “KA21 strain” cultivated in Brazil is rich in “β-glucan” and vitamin D, which are the main components. The company is accumulating evidence for this material in a wide range of fields such as immunity and cosmetology. In the area of immunity, various tests have confirmed the activating and antitumor effects of NK (natural killer) cells. Animal studies have also revealed antiviral effects and effects that reduce the side effects of anticancer drugs.
The results of the new human clinical trial were published in the international journal of medicinal mushrooms, the International Journal of Medical Mushrooms.
In the same study, 22 healthy subjects were divided into two groups: (1) KA21 strain 900 mg intake group and (2) 1500 mg intake group, and were given for 12 weeks.
As a result, it was confirmed that the IgG / M / A antibody titer against β-glucan derived from the pathogenic fungus “Candida” was significantly increased in both the 900 mg intake group and the 1500 mg intake group compared to the pre-ingestion group. A significant increase in IgG antibody titer was also confirmed in the 1500 mg intake group.
The IgG antibody titer against β-glucan derived from the same pathogenic fungus “Aspergillus” was also significantly increased in the 1500 mg intake group.
So far, in conventional clinical trials in healthy subjects, it has been confirmed that 3000 mg of KA21 strain per day for 3 months has an effect of increasing IgA antibody titer against fungi. In this study, it was shown that even lower doses and shorter intake times than before may activate the immune system and exert its usefulness against fungal infections such as Candida and Trichophyton.
Also confirmed to have antiviral effect
It has also been confirmed in several studies that the KA21 strain has an antiviral effect.
In a test in which the effect on feline calicivirus and murine norovirus was investigated by the plaque method (see *), it was confirmed that the higher the concentration of the KA21 strain, the smaller the plaque size of the virus used. The virus infection titer was reduced by inoculation of the KA21 strain.
In the culture supernatant cultured with the addition of the KA21 strain, a significant decrease in virus titer was confirmed in the control ratio 24 hours after virus inoculation. It was also found that the virus titer of the virus used in the culture supernatant during 24-hour culture decreased as the concentration of the KA21 strain increased.
From these results, it was shown that the antiviral effect of the KA21 strain increased as the concentration increased.
Past studies have shown similar results for the influenza virus.
The antiviral effect has also been confirmed in animal tests using mice. In the same study, ingestion of Agaricus was confirmed to promote the in vitro excretion of murine norovirus.
In addition, regarding immunity, activation of NK cells was confirmed by human clinical trials. In a basic study in which agaricus hot water extract was orally administered to a cancer-bearing mouse model using tumor cells, an antitumor effect and suppression of inflammatory cytokines were confirmed, such as a tumor shrinkage effect. ..
* The plaque method is a method of analyzing the virus infectious titer (the number of virus particles with cell infectivity) using the phenomenon that cells that have died due to virus infection / proliferation remain in spots (plaque = lytic spots).