Chelsea overcame the defeat of the Carabao Cup final behind, claiming London the right to boast against rivals Tottenham Hotspur.
On the other hand, Manchester City kept the heat on Liverpool after his emphatic victory over Watford by deploying West Ham to Etihad.
Manchester United and Arsenal have also won victories in the capital, while Southampton has accumulated more misery for the ill-fated Fulham.
Scroll down for a full review of all Premier League actions from Wednesday night!
ARSENAL 5-1 BOURNEMOUTH
The hosts unlocked the stall after just four minutes when Mesut Ozil called home his fifth goal of the season.
Sead Kolasinac played the German and cut the ball over the impetuous Artur Boruc.
Henrikh Mkhitaryan doubled the advantage of Arsenal to 27, after a brilliant connection with Ozil.
But Bournemouth scored a goal on the half hour when Lys Mousset fired after Dan Gosling had taken the ball from Matteo Guendouzi.
Arsenal scored 3-1 less than two minutes after the restart, with Laurent Koscielny achieving the goal.
Shortly after Ozil touched carpentry, Arsenal scored 4-1 with Pierre-Emerick Aubameyang.
A free kick by substitute Alexandre Lacazette leads Arsenal 5-1 to 12 minutes before the end.
SOUTHAMPTON 2-0 FULHAM
Southampton striker Charlie Austin put the ball in the early stages, nodding home from close range, but was dismissed after being found guilty of Fulham goalkeeper Sergio Rico.
However, the hosts went ahead in the 23rdrd minute when Oriel Romeu drove home from the edge of the area, after goalkeeper Rico punched a corner on the right.
James Ward-Prowse put Southampton on 2-0 at 41.
Nathan Redmond's shot from the edge of the area was sent off by Rico, but Ward-Prowse was careful to hit the rebound at home.
LIVERPOOL 5-1 WATFORD
Liverpool has reminded everyone that they are still firmly in command of the title race with an emphatic victory over Watford at Anfield.
The Reds, who had drawn four of their last five games in all competitions, needed only nine minutes to open the score.
The hosts enjoyed the lion's share of possession and territory in the early stages and were rewarded when Trent Alexander-Arnold's cross was expertly directed into the upper corner by Sadio Mane.
While Origi seemed to be a little rusty on the left wing, Mane was taking full advantage of the central role in the absence of Firmino.
The national team of Senegal has doubled the home team's lead to 20 & rsquo; after another pass by Alexander-Arnold in the area.
Salah, as often happens, was showing a handful on the right channel for Liverpool and the 26-year-old again tested Foster from a sharp angle after making his way into the area.
A block on Craig Cathcart's last stop prevented Mane from potentially sealing his hat-trick.
But Origi cut from the left and drove just over Foster on his first post to put Liverpool in the lead 3-0 to 66 & # 39 ;.
Mane took a touch and then, with his back to the door, lifted the ball on a baffled Ben Foster with a bold back heel that lurked in the net.
The influential Alexander-Arnold had his third assist of the evening, taking care of a free kick at the far post, where Virgil Van Dijk beat the header on Foster with 11 minutes left.
Van Dijk got his second of the evening's moments later with a header from Andrew Robertson in the area.
MANCHESTER CITY 1-0 WEST HAM
The city assured that they kept the pressure on the leaders of Liverpool with a comfortable victory at Etihad against West Ham.
Manuel Pellegrini surprised many fans at Etihad by giving defender Ben Johnson an advantage over the left-back in place of injured Aaron Cresswell.
City and West Ham entered the interval with a score of 0-0 after the hosts had mastered possession but failed to make the most of it.
The men closest to Pep Guardiola went to the goal in the fourth minute when David Silva met Kevin De Bruyne's delivery and fired at a post.
The city took the lead on 59 minutes thanks to a penalty from Sergio Aguero, awarded after Felipe Anderson knocked down Bernardo Silva.
Aguero sent Lukasz Fabianski in the wrong way, recording his eighteenth goal in the league.
CHELSEA 2-0 TOTTENHAM
Chelsea may have left Kepa Arrizabalaga on the bench for Tottenham's visit, but it was their strikers who became the opening titles of Stamford Bridge.
Gonzalo Higuain hit the post after half an hour when he cut a flurry from the edge of the area.
Spurs striker Harry Kane was involved in an altercation with Cesar Azpilicueta, who seems to move his head towards the Chelsea defender, but the referee Andre Marriner did nothing.
And it was Spurs' turn to hit the balustrade in the middle of the first half, when Harry Winks threw a shot to hit the crossbar, but the first half ended in scoreless net.
Chelsea took the lead on 57 minutes when Pedro entered the field behind Toby Alderweireld and fired on Hugo Lloris's legs.
The hosts signed the victory when a defensive mix saw Tottenham defender Kieran Trippier turn the ball into his own net six minutes before the end.
CRYSTAL PALACE 1-3 MANCHESTER UNITED
A wounded Manchester United managed to put Crystal Palace to the sword, despite his weakened side.
United unlocked the time 37 minutes into the game when Romelu Lukaku fired the ball from Vicente Guaita.
Having lost a first chance in the box when not scored, the Belgian has approached a sumptuous attempt to right after a run unbridled by the imposing Luke Shaw.
Lukaku scored his second international and United goal in the night of the 52nd, when Belgium scored a goal in the area after a scorer struck after Ashley Young's corner .
Palazzo reduced the deficit to just one goal when Joel Ward scored 2-1, coming home to 66 & # 39 ;.
Ashley Young gave space to United's breath when he scored 3-1 at 83. "
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