Manager Ole Gunnar Solskjaer wants the Old Trafford to evoke the spirit of the famous European nights when Barcelona visits to meet his Manchester United team in the Champions League quarter-finals.
The United boss says his players believe that another Champions League scalp is possible against the Spanish champions.
"Obviously when you arrive in Barcelona, with the quality of their team, we know we need to improve our game," said Solskjaer.
"We know we have to perform at our best levels, which we do not have against PSG at home. The outcome of the second leg against PSG gave players and fans the conviction that the same is possible against Barcelona" .
The former Manchester United man, Gerard Pique, said that, before his return to the Old Trafford, Barcelona will not underestimate the English side. Pique stressed the need to be ruthless against the king of Manchester United.
Pique said: "The match against PSG is a good example.
"They (PSG) were better, but you can't leave United out of trouble because they have a great team and a great story as they showed in Paris.
"We learned (from Rome) that things happen, even if it seemed unimaginable that they would do it. We have learned that you cannot allow an opponent to return in a draw if they are not eliminated. This will help us to face a team like United.
"If at any time we can kill the bond, we have to do it."
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Manchester United vs Barcelona teams
Manchester United (probably XI): De Gea; Young, Smalling, Lindelöf, Shaw; Matić, Herrera, Pogba; Lingard, Rashford; Martial
On: Bailly (concussion), Darmian (unknown), Sánchez (knee), Valencia (fitness)
doubtful: Herrera (unknown), Matić (unspecified), Rashford (ankle)
The next game is missing if booked: Herrera, Matić, Shaw, Valencia, Young
Barcelona (probably XI): Ter Stegen; Semedo, Piqué, Lenglet, Alba; Vidal, Arthur, Busquets, Rakitić; Messi, Suárez
On: Rafinha (knee)
doubtful: Dembélé (biceps femoris)
The next game is missing if booked: Semedo