We will explain the basic operation method and operation tips of the system that predicts the toxicity of chemical substances, with demonstrations.
The National Institute of Technology and Evaluation (NITE) will hold the “FY2022 QSAR Read-Across Seminar” on October 17, 2022 (Monday) under the support of the Ministry of the Environment’s Minister’s Secretariat, Environmental Health Department. It will be held online (free).
In this course, we will explain the basics of read-across, which is one of the alternatives to animal testing, and the QSAR Toolbox and HESS, which are systems that support it, and explain their basic operation methods.
In addition, an overview of the KAshinhou Tool for Ecotoxicity (KATE) will be provided by the National Institute for Environmental Studies and a course on how to operate it will be provided. In addition, the National Institute of Health Sciences will give a lecture on QSAR utilization cases related to human health effects.
Proper use of these systems makes it possible to predict the toxicity, etc. of chemical substances. In this workshop, we will explain the basic operation method with demonstration. We look forward to your participation.
Overview of QSAR (*1) / Read-Across (*2) Workshop
At NITE, in order to promote the use of predictive methods in chemical safety assessment, we are working on the basics of read-across, which is one of the alternatives to animal testing, and the QSAR Toolbox (*3) and HESS (*4) systems that support it. ) has been held since 2012.
QSAR/read-across is a method for estimating or analogizing the toxicity and properties of untested substances from similar substances with test data, and its use in chemical product regulations is being promoted internationally.
The QSAR Toolbox is a read-across support system for skin sensitization and other toxicity, environmental dynamics, and properties of chemical substances. HESS is a system specialized for repeated dose toxicity and published by NITE.
Quantitative Structure-Activity Relationship
By inputting the chemical structure of a target substance, prediction results such as toxicity of the substance can be quantitatively obtained from the structure-activity relationship model.
A method in which an evaluator collects and organizes information such as the toxicity of substances that have similar structures to the target chemical substance when evaluating (toxicity, etc.) of chemical substances, and makes predictions (judgments) by expert judges. As a powerful alternative to animal testing, its use in chemical regulations is being promoted internationally.
※3 QSAR Toolbox：
The OECD QSAR Toolbox is equipped with various tools for selecting similar substances and a database of various test data, and is a system that enables sharing and efficient acquisition of information necessary for read-across evaluation with others. .
*4 HESS: Hazard Evaluation Support System Integrated Platform (HESS) is a system for supporting read-across repeated dose toxicity evaluations. A system similar in structure to the OECD QSAR Toolbox, but specialized in evaluating repeated dose toxicity A detailed database (toxicity test data, Toxicity mechanism information, ADME information, etc.).
Outline of Ecotoxicity Prediction System (KAshinhou Tool for Ecotoxicity: KATE)
KATE is a prediction system specializing in ecotoxicity developed by the Ministry of the Environment and the National Institute for Environmental Studies, and is open to the public at the Environmental Risk and Health Research Center of the National Institute for Environmental Studies. The purpose of this system is to predict ecotoxicity such as the median lethal concentration (LC50) in fish acute toxicity tests and the median effective concentration (EC50) in daphnia immobility tests from the partial structure of chemical substances. About KATE (National Institute for Environmental Studies)＞＞＞ https://kate.nies.go.jp/index.html
Overview of the event
Name: FY2020 QSAR/Read Across Seminar
Date and time: October 17, 2022 (Monday) 10: 00-16: 15
Target audience: Beginners of read-across
Holding format: Online seminar using Webex webinar
Cost: Free (advance application required, deadline as soon as capacity is reached)
Basics of QSAR/read-across
(Germany) National Institute of Technology and Evaluation Yuki Sakuraya
QSAR related to biodegradability and accumulation
(Germany) National Institute of Technology and Evaluation Yuri Zaitsu
Ecotoxicity prediction system “KATE” (provisional)
Koichi Ohno, Director, Environmental Risk Science Research Promotion Office, Environmental Risk and Health Area, National Institute for Environmental Studies
QSARs and read-across related to human health effects
National Institute of Health Sciences Safety Biology Research Center Safety Prediction Evaluation Department 4th Office Manager Takashi Yamada
Instructions on how to use KATE (provisional)
Midori Goto, Advanced Skilled Expert, National Institute for Environmental Studies
QSAR Toolbox Overview and Operation Instructions
(Germany) National Institute of Technology and Evaluation Shino Kuwa
Overview of HESS and operation explanation
(Germany) National Institute of Technology and Evaluation Michiko Watanabe
Overview of the National Institute of Technology and Evaluation, Chemical Management Center
The NITE Chemical Substances Management Center is in compliance with the Law Concerning the Examination and Regulation of Manufacture, etc. of Chemical Substances (Chemical Substances Control Law), which is under the jurisdiction of the Ministry of Economy, Trade and Industry, and the Understanding, Etc., and Improvement of Management of Specific Chemical Substances Released into the Environment. We provide technical support for the enforcement of the Law Concerning the Promotion of Chemicals (PRTR Law). We also conduct on-site inspections and international inspections based on the Act on the Prohibition of Chemical Weapons and the Control of Specified Substances (Chemical Weapons Act). In addition, we collect, organize, and provide information on the risks of chemical substances, such as toxicity.
▲[NITE Detective of the Hawk’s Claw Team]Introducing the work of the Chemical Center in an easy-to-understand manner ▲
Chemical Substance Management | Chemical Substance Management | National Institute of Technology and Evaluation (nite.go.jp)
Introduction of NITE courses
In addition to the “QSAR/Read-Across Workshop”, NITE also holds “NITE Lectures (Free Seminars)” for the general public and businesses.
In this year’s “NITE course”, we will discuss “product conformity assessment system”, “ensuring the safety of familiar household products”, “risk assessment and appropriate management of chemical substances”, and “bio-manufacturing”. Seminars will be held on the themes of “Utilization of microbes” and “Safety evaluation of large-scale storage battery systems, etc. necessary for the realization of carbon neutrality”.
For details and application, please check the NITE HP below.
NITE course information ＞＞ https://www.nite.go.jp/nite/koho/event/kouza/2022fy.html