Intervention lowers aspirin use in individuals with atrial fibrillation, VTE usually takes warfarin, and improves end result

In patients with no evident indication for concomitant antithrombotic treatment treated with warfarin for atrial fibrillation (AF) and/or venous thromboembolism (VTE), a multicenter aspirin deprescribing intervention resulted in extreme Aspirin use lessened drastically.

A “decommissioning” method was related with a almost 50% reduction in total aspirin use in six anticoagulation clinics, substantially cutting down bleeding events and enhancing wellbeing outcomes devoid of growing thrombotic results. It was involved with decreased use of care.

Geoffrey D. Barnes, MD, MSc, Assistant Professor, Cardiovascular and Vascular Drugs, University of Michigan Well being Technique, Led by examine authors, for some sufferers with atrial fibrillation or VTE soon after acute coronary syndrome or percutaneous remedy , wrote that aspirin is correctly blended with warfarin. Coronary interventions, and also in some patients with mechanical heart valves.

On the other hand, for most other clients, the evidence suggests that the harm outweighs the benefits of combinations that raise the possibility of bleeding occasions devoid of plainly lowering thrombotic results, the authors explained. additional. Although clinical recommendations do not recommend this practice, researchers observed that “numerous sufferers surface to be getting aspirin, even when the possible threats outweigh the advantages.” states.


Nevertheless, for most other patients, the proof suggests that the mixed use of aspirin and warfarin does more damage than fantastic, with out evidently lowering thrombotic results and escalating the hazard of bleeding activities.


Barnes et al. executed a pre-submit observational top quality improvement research applying a affected person population attending six Michigan Anticoagulant Excellent Improvement Initiative (MAQI) clinical sites to detect clients who have been most likely to be unsure about aspirin use. Pre-intervention and submit-intervention rates and the influence of aspirin were assessed. Interventions for scientific outcomes.

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Each individual of the 6 MAQI clinics used a web page-distinct screening approach to detect sufferers receiving aspirin without the need of a apparent indication and collected details concerning January 2010 and December 2019 Did. In accordance to the examine, the top quality advancement intervention took location involving Oct 2017 and June 2018.

For clients in whom aspirin indications are unclear or appear inappropriate, session with the patient’s clinician or expert may possibly be the cause for discontinuation.

Indications for aspirin use ended up assessed at enrollment in the pre-intervention cohort and at enrollment in the article-intervention cohort or at the to start with abide by-up right after implementation of the intervention.

The MAQI followed 6,738 clients (signify age 62.8 several years, 46.9% male) identified as becoming treated with warfarin without indication for aspirin for a median of 6.7 months. Much more than half (55.1%) ended up obtaining anticoagulant therapy for her VTE.

All round, surplus aspirin use just after the withdrawal intervention diminished by nearly 50% from 29.4% to 15.7%.

Precisely, information described by Barnes and colleagues present that aspirin use across MAQI web pages diverse from baseline indicate 29.4% (95% CI, 28.9% – 29.9%) to 27.1% (95% CI, 26.1% – 28.%). ) throughout the 24-thirty day period preintervention interval (P. < .001 for slopes 24 months before and 24 months after intervention).

After the intervention, the decline in aspirin use accelerated significantly by a mean of 15.7% (95% CI, 14.8% – 16.5%), a trajectory noted by the authors that was steeper than that seen in the preintervention period. (P. = .001 slope before and after intervention).

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Overall, aspirin overuse decreased by nearly 50% from 29.4% to 15.7% after the withdrawal intervention.


Results of the primary analysis showed a significant reduction in major bleeding events per month (pre-intervention, 0.31% 95% CI, 0.27%-0.34% post-intervention, 0.21% 95% CI, 0.14% -0.28% 95% CI, 0.14%–0.28% P.= .03 (difference in slope before and after intervention). Notably, the mean proportion of patients with thrombotic events did not significantly change before and after the intervention (0.21% vs. 0.24% P.= .34 slope difference).

In a secondary analysis, the research team found that reducing aspirin use (beginning 24 months before stopping the intervention) was associated with a reduction in the average percentage of patients.

  • have a bleeding event (2.3% vs 1.5% P.= .02 for change in slope 24 months before and 24 months after intervention)
  • have a major bleeding event (0.31% vs 0.25% P.= .001 for change in slope 24 months before and 24 months after intervention)
  • in the emergency room bleeding (0.99% vs 0.67% P.= .04 for change in slope 24 months before and 24 months after intervention)

“Our findings highlight the need to intensify aspirin management among patients receiving warfarin for anticoagulant therapy,” Barnes and colleagues wrote. The success of interventions across multiple health care systems with different and clinical structures has been linked to aspirin overuse.”

“Given that aspirin is not a prescription drug, clinicians may not always be aware that patients are taking aspirin, which presents a barrier to aspirin discontinuation efforts. may be,” they add.

They wanted to determine whether aspirin withdrawal for patients receiving newer direct oral anticoagulants was similarly efficacious, and to confirm the current findings “ideally in a control group.” We are seeking additional research on

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References: Schaefer JK, Ericsson J, Gu X, et al. Evaluation of interventions to reduce aspirin prescriptions for patients receiving warfarin for anticoagulation. JAMA net opened. 20225(9):e2231973.doi:10.1001/jamanetworkopen.2022.31973


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