There was a slight deterioration of APS in both groups, with no significant differences between naproxen and placebo. In the verum group there were more and more NSAID-typical side effects such as constipation, dyspnea, hypertension and petechies. "Although we see the known adverse effects, but not the least indication of an advantage," Meyer said in a press release. The researchers see in their research the end of studies with NSAIDs with a view to Alzheimer's disease. They point out that many other approaches to Alzheimer's are being tested. Against this background, the publication of negative results such as theirs is hugely important, the scientists say.