Exercise promotes neural stem cell transplantation in the treatment of stroke and has made important progress in animal experiments — ScienceDaily

Exercise promotes neural stem cell transplantation in the treatment of stroke and has made important progress in animal experiments

When: January 15, 2022

Source: Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences

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The related results were published in the international academic journal Stem Cell Reports on January 13 under the title Physical exercise promotes integration of grafted cells and function recovery in an acute stroke rat model

Stroke has become one of the main causes of death and disability in adults worldwide, and the morbidity and mortality of stroke in China is the highest in the world. With the advancement of medicine, the survival rate of stroke patients has been improved, but more than 80% of the survivors are left with neurological dysfunction, such as the most common motor sensory dysfunction. There is currently no effective treatment. Cell replacement therapy represented by neural stem cells is expected to bring hope for the cure of related diseases. However, whether the transplanted neural stem cells can integrate with the host nervous system and have in vivo functions is still questionable, which seriously hinders the clinical translational application of neural stem cell therapy.

The team of researcher Pan Guangjin of Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences and the team of professor Hu Xiquan, a neurorehabilitation expert from the Third Affiliated Hospital of Sun Yat-sen University, used ischemic stroke (MCAO) animals as models to carry out in-depth cooperation in neural stem cell therapy. Neural stem cell transplantation combined with exercise training has made important progress in promoting the in vivo maturation of transplanted nerve cells and the restoration of animal behavioral functions. The related results were published in the international academic journal Stem Cell Reports on January 13 with the title Physical exercise promotes integration of grafted cells and function recovery in an acute stroke rat model.

Neuroscientists now generally recognize that it takes a long time for human nerve cells to mature in vivo. Most studies show that it takes half a year to more than one year, so it is easy to miss the best time window for rehabilitation after stroke. This study found that timely exercise training after surgery can significantly promote the differentiation and maturation of transplanted human neural stem cells, and form neural circuits with host neurons, shortening the process to 1-3 months. The experimental group of cell transplantation combined with exercise training was significantly better than the injured control group, single-cell transplantation and single-exercise training group in terms of cerebral infarction volume, neuron differentiation and maturation, and host neurovascular regeneration, and also in terms of motor function recovery. optimal. Further mechanistic studies showed that the combined interventional approach created an intracerebral microenvironment that was conducive to neuronal survival and regeneration: the level of neurotrophic factors in the lesion was significantly increased, angiogenesis was enhanced, and the levels of inflammation and oxidative stress were significantly decreased; another On the other hand, synapses (connections between neurons) and neuroplasticity are activity-dependent, and exercise training causes a significant increase in the activity levels of related synapses and neurotransmitters, thereby promoting the reconstruction of damaged neural circuits and Recovery of motor function.

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Exercise training has been widely used for recovery after brain injury due to its non-invasiveness, safety and low risk, and no side effects. This study further shows that exercise training can promote the maturation and integration of transplanted cells, and the combined intervention of neural stem cell transplantation and exercise training is expected to provide new treatment options for related neurological diseases, which is of positive significance for promoting the clinical application of neural stem cells.

The corresponding authors of the paper are Pan Guangjin and Hu Xiquan. Wu Rui, a doctoral student of Sun Yat-sen University, Guo Yiping, an associate researcher of Guangzhou Health Institute, and Zhang Liying, a physician of the Third Affiliated Hospital of Sun Yat-sen University, are the co-first authors of this paper. The research was supported by projects from the National Natural Science Foundation of China, Guangdong Province and Guangzhou City.

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  Mouse experiments show that rehabilitation training promotes the maturation and circuit reconstruction of transplanted nerve cells (Photo courtesy of Guangzhou Health Institute)

  

  

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