Coronary collaterals offer major perfusion in CAD

The review included in this summary was published on as a preprint and has not nonetheless been peer-reviewed.

Takeaway essential

  • In the to start with research to explain the extent of coronary microvascular collateral perfusion, the scientists uncovered that 60% of the perfusion in the compromised myocardium is furnished by collaterals, in spite of coronary occlusion and the absence of angiographically obvious collateral vessels.

Why this is vital

  • The presence of collaterals has been revealed to be associated with improved outcomes in clients with CAD. However, for the initially time, the extent of myocardial perfusion provided by the collateral circulation for the duration of experimental balloon occlusion is described.

Research design and style

  • In a retrospective substudy of a greater cohort, clients with no heritage of prior myocardial infarction, bypass operation, or angiographically noticeable collaterals underwent elective percutaneous transluminal coronary angioplasty (PTCA) on a solitary coronary vessel amongst September 1995 and April. 1996.

  • 1100 MBq of 99 mTc-sestamibi was injected just after 3 minutes of entire intracoronary balloon inflation and SPECT imaging of the vessels happened within 3 hrs of injection (occlusion examine). A next SPECT imaging review the working day after PTC with 1100 MBq’s 99 mTc-sestamibi was performed (regulate analyze).

  • The connection involving occlusion and extent of perfusion was calculated amongst the occlusion and handle reports. Statistical evaluation was carried out working with R program and differences in between teams have been examined working with Wilcoxon’s examination. A P. price <.05 was considered statistically significant.

Key findings

  • PTCA was performed in 21 patients with a mean balloon occlusion time of 5 minutes.

  • The size of the perfusion defect was 16% of the left ventricle, and the collateral perfusion within the perfusion defect was 64% of the normal perfusion within that region for the entire cohort.

  • Collateral perfusion was negatively related to the size of the perfusion defect (R.2 = 0.85 P. <.001). Smaller perfusion defects had greater collateral perfusion than larger perfusion defects, but they did not differ in age or gender.

  • On average, despite coronary occlusion and the absence of angiographically visible collateral vessels, collaterals provide 60% of the perfusion reaching the compromised myocardium.


  • The study included only 21 patients, but was considered adequate for a point estimate and provided sufficient variability for the myocardium subtended by an occluded coronary artery.

  • Absorption of 99 mTc-sestamibi after balloon deflation could potentially erroneously raise estimates of collateral perfusion. Since the median injection time of the balloon was 5 minutes and 8%. 99 mTc-sestamibi remains in the bloodstream after 5 minutes, the measured perfusion results may have been overestimated by 8%.

  • Contralateral vessel angiography was not performed during balloon angioplasty inflation in this study. It is not known whether collateral vessels can be viewed angiographically during balloon occlusion.

  • The analysis was performed on images not corrected for attenuation, which could overestimate the perfusion defect by 3%.


This is a summary of a preliminary research study, “Coronary collaterals not visible from invasive angiography can provide more than half of the normal resting perfusion in patients with coronary artery disease,” written by Brandon Harris, Ravinay Bhindi, MBBS, PhD, Martin Ugander, MD, PhD, and Usaid Allahwala, MBBS, PhD, of the Kolling Institute at Royal North Shore Hospital and the University of Sydney, Australia. Stafford Warren, MD, of the Anne Arundel Medical Center in Annapolis, MD, also contributed. Eva Persson, MD, PhD, from the Department of Clinical Physiology and Skane University Hospital in Lund, Sweden also contributed. Michael Ringborn, MD, PhD, of the Thoracic Center of Blekinge Country Hospital in Karlskrona, Sweden also contributed. This medRxiv study is provided to you by Medscape.

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